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🌸 Join us this spring 🌸
During the spring 2024, Microphyt will be present at several industry events. We hope to take this opportunity to meet you and share with you about our unique ingredients extracted from microalgae. Come and join us to these various events:
March 19-21st: BIOKET:
Location: France, Reims, Congress Center
March 29th: SFEL Webinar – Jonathan Maury, Clinical Research Manager at Microphyt, will be taking part during a webinar organized by SEFL (Société Française pour l’Etude des Lipides). He will present the results of our latest nutraceutical clinical study “Effects of fucoxanthin and fatty acids containing microalgae supplementation on body composition and markers of health in overweight women participating in an exercise and weight loss program”
April 16-18th: In Cosmetics global – Come back to Paris! Microphyt will exhibit on In-Cosmetics global event, the leading global event for personal care ingredients, and will notably unveil its new innovative bioactive ingredient for the cosmetic industry. Book appointments in advance to discuss with the cosmetic team: Vincent Usache, CEO Laura Bertrand, Business Developer, Cyrielle Houdin, Marketing Manager Advanced Beauty, Mélanie Lefevre, Cosmetic Application Manager and Clémentine Depresle Product Manager Cosmetic Ingredients. Visit us at booth 1R85 to try our new bioactives.
Book an appointment: contact@microphyt.eu
Location : France, Paris, Paris Expo Porte de Versailles
May 14-16th: Vitafoods Europe – Like every year, Microphyt will exhibit to Vitafoods, The World’s Nutraceutical Event! The perfect place to meet leading suppliers of raw ingredients, dietary supplements such as Microphyt, functional food and stuff. Please come and visit us at our booth H56 on algae pavilion. Vincent Usache, CEO and Christel Lemaire, Marketing Manager for Novel Nutrition will be there to discuss about sustainability challenges and how microalgae can help to face it.
Book an appointment: contact@microphyt.eu
Place: Switzerland, Geneva, Palexpo
June 5-6th: Cosmetic Business Munich – For its first exhibition in Germany, the cosmetic team chose CB Munich.As the only international trade show in Germany, it brings together exclusively cosmetics companies and all their suppliers for the development, production, packaging and marketing of the entire range of cosmetics products. As a barometer of mood and trends, it is indispensable to decision-makers in the sector. Laura Bertrand and Cyrielle Houdin will welcome you at booth 1D22.
Book an appointment: contact@microphyt.eu
Place: Germany, Munich, MOC Event Center
June 10th: DSHEA Summit – Microphyt will be present to discuss about the Dietary Supplement Health and Education Act. The program aims to delve into the historical, current, and future aspects of the US dietary supplements industry.
Place: USA, Salt Lake City, Hyatt Regency
June 11th: COSMED visit – COSMED and COSMETOPOLE organize a thematic day on water management in cosmetic in Montpellier. For this occasion, Microphyt offers factory’s visit. It’s the opportunity to discuss how can we improve water management within biotechnology industry. Cosmetic team will be present to welcome you.
More information and registration here
Place: France, Montpellier
June 18-20th: Nutriform Business Days – 3 days of sharing and exchange, conferences and round tables to discuss the latest international developments in food supplements, where Christel Lemaire will be present for this 8th edition.
Place: France, Antibes Juan les Pins, Congress center
June 18-20th: ISSN – Microphyt will be attending the International Society of Sports Nutrition Summit. Our Clinical Research Manager Jonathan Maury will present the science behind Phaeoptim™, our nutraceutical novel ingredient to naturally optimize healthy active lifestyle benefits, during a 30-min presentation session. Stefan Wypyszyk, Chief Commercial Officer will be there to introduce you our ingredients.
Place: USA, Bonita Spring, Hyatt Regency
July 29th-August 1st: NBJ Summit – Before summer break, why not meeting Vincent Usache and Stefan Wypyszyk at the Nutrition Business Journal where natural products and nutrition industry’s most influential minds are joining to learn about future trends while networking with all the industry leaders
Place: USA, Palos Verdes, Terranea Resort
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
Microphyt’s team
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Microphyt to Showcase Microalgae-based Ingredients at SupplySide West in Las Vegas Oct. 25-26
Visitors may sample gummies containing patented microalgae-extracts supporting cognition, metabolic wellness and healthy lifestyles.
MICROPHYT TO SHOWCASE ITS UNIQUE SOLUTIONS AT SUPPLYSIDE WEST
Microphyt will showcase its innovative microalgae-based cognitive health, metabolic wellness and active lifestyle solutions at booth #4442 during SupplySide West, an international gathering of health and nutrition industry experts taking place from October 23-27 at Mandalay Bay, Las Vegas.
The company’s patented technology enables the cultivation of any kind of microalgae, even delicate strains previously deemed unviable. Its research is focused on identifying specific bioactives – secondary metabolites naturally produced by adaptive microalgae – that target promising pathways vital for improving human health. Microphyt’s dietary supplement ingredients are produced in environmentally controlled eco-friendly photobioreactors free of GMO, pollutants or pesticides.
“Our goal is to unlock the potential of microalgae for improving human health,” said Vincent Usache, Microphyt Chief Executive Officer. “We are delighted to present our innovative products, which offer sustainable solutions for healthy aging, cognition and metabolic wellness.”
SupplySide West visitors can sample tablets, softgels, capsules and gummies of Microphyt ingredients derived from Phaeodactylum tricornutum. This marine microalga is rich in natural antioxidants, including fucoxanthin, Omega 3 fatty acids (EPA & DHA), essential amino acids, and vitamins and minerals.
THREE INNOVATIVE INGREDIENTS WITH CLINICALLY PROVEN EFFICACY
1/ NEW: PhaeOptim™ naturally supports metabolic wellness and active and healthy lifestyles vital to healthy weight management. A randomized 12-week clinical study of 37 overweight women included a supervised exercise training and a diet intervention plan. Subjects also taking 220mg/day of PhaeOptim had significant improvements in exercise capacity and cardiovascular health. PhaeOptim also helps healthy bones endure the stress of exercise.
2/ GamePhyt™ is a natural bioactive complex clinically proven to improve the cognitive performance of gamers. GamePhyt is a combination of the extract of Phaeodactylum tricornutum and guarana extract that improves memory, mental sharpness, energy and endurance. A clinical study of 61 experienced gamers published in Nutrients this year showed improved cognitive performance after single dose and increased gaming performance after 30 days of supplementation. Benefits included improved reaction time, accuracy, processing speed, focus, decision-making, mental energy. GamePhyt also supported mood, sleep quality and visual comfort.
3/ BrainPhyt™ is designed for healthy aging and maintenance of cognitive function. BrainPhyt improves short and long term and spatial memory and reduces oxidative stress and the inflammatory biomarker IL-6 in the brain. A six-month randomized placebo-controlled clinical study with 66 healthy elderly subjects demonstrated BrainPhyt improved long-term memory, increased attention and vigilance, and reduced stress and C-reactive protein concentration in the blood. Numerous preclinical studies demonstrate BrainPhyt’s superior ability to improve and maintain brain function compared with DHA alone and Ginkgo biloba extract.
To make an appointment, write to us at contact@microphyt.eu or fill in the contact form here.
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Unlocking the Potential of Microalgae: A Look at Their Benefits and Applications
Microalgae are an ideal solution when it comes to meeting environmental challenges and consumers’ high expectations in terms of a healthy and sustainable lifestyle. Here’s an overview of the benefits of these super ingredients.
As the world’s population grows and the need for sustainable alternatives to fossil fuels becomes more pressing, microalgae are emerging as a viable alternative. Microalgae were among the first life forms to appear on Earth, creating oxygen through photosynthesis and laying the foundation for all plant life on our planet. These microscopic marine organisms are now being researched for their potential in multiple fields, including nutrition, environmental science, well-being and cosmetics. With their ability to reduce carbon dioxide emissions, high nutritional value, and potential for industrial applications, microalgae are becoming a promising solution for a sustainable blue future. In this article, we will explore the numerous benefits of microalgae and how they can be integrated into our daily lives.
The Environmental Benefits of Microalgae: A Promising Solution for Sustainable Development
The environmental benefits of microalgae are numerous and particularly promising in terms of sustainable agriculture. One of the most significant advantages of microalgae is their high biomass yield and their ability to grow quickly. As a result, they can produce more protein using less time and resources, as well as less land, water, and other inputs, compared to traditional crops and livestock. Microalgae have been found to be capable of producing more than twice the amount of protein contained in soya beans. Furthermore, microalgae can be grown in various locations, including areas that are unsuitable for traditional crops, such as deserts and arid regions, without competing with other crops for land. As a result, microalgae-based systems can help reduce pressure on natural resources, minimize land use, and promote sustainable agriculture. Microalgae, through the process of photosynthesis, utilize sunlight to convert carbon dioxide into organic compounds, enabling their growth and development. This ability of microalgae to fix high quantity of carbon dioxide from the atmosphere offers significant environmental benefits, making them a promising resource for mitigating climate change and reducing greenhouse gas emissions. Overall, the high biomass yield and efficiency of microalgae make them an excellent solution for addressing some of the most pressing environmental challenges we face today, and they have the potential to play a significant role in creating a greener, more sustainable future.
The Nutritional Benefits of Microalgae: A Promising Future for the Food Industry
Microalgae are often referred to as “superfoods” due to their exceptional nutritional profile. First step in the aquatic food chain, their strength lies in their capacity to naturally generate and concentrate a significant number of active compounds, including carbohydrates, lipids, vitamins, trace minerals (such as copper, iron, and zinc), mineral salts, carotenoids, and additional antioxidants. More importantly, microalgae are a rich source of protein, with some species containing up to 70% protein by weight. This high protein content makes microalgae a particularly valuable source of nutrition for vegetarians and vegans who may struggle to meet their protein requirements through a plant-based diet. Furthermore, microalgae are an excellent source of omega-3 fatty acids, which are essential for maintaining heart health, reducing oxidative stress, and improving brain function. These fatty acids are originally synthesized by microalgae and typically found in fish oil via the food chain.
In addition, microalgae offer an incredible source of bioactive molecules, providing high-value nutritional ingredients with powerful benefits for health and well-being. For instance, Fucoxanthin is a molecule found naturally in some algae and microalgae, such as Phaeodactylum tricornutum. This pigment from the carotenoid family is a powerful antioxidant which protects the body’s cells from free radicals and therefore also from the effects of aging. Microalgae are a powerhouse of essential nutrients, making them a valuable component of a healthy, balanced diet and offer a more sustainable, plant-based alternative.
Thanks to their benefits, microalgae can diversify the sector of food supplements in many segments such as cognition, sports nutrition, weight management, joint health, digestive comfort and overall immunity, providing safe products with nutritional and health benefits for the end user.
Microalgae also show great promise in the field of animal nutrition. The need for protein sources for livestock, especially for aquaculture, is a major environmental concern. The traditional sources of protein for animal feed are often associated with resource-intensive production processes that can result in deforestation, habitat loss, and overfishing. Microalgae represent a promising sustainable solution to replace a portion of the current livestock feed, which predominantly comprises animal meal, along with vegetable meal.
Beyond Nutrition: The Many Benefits of Microalgae
The unique properties of microalgae make them a versatile and sustainable source of raw materials for a range of applications in various industries. One of the most significant and fastest-growing sectors is the cosmetics industry, where microalgae-derived ingredients are increasingly used in skin and hair care products. Microalgae, due to the specific active compounds they contain, make it possible to open new territories of innovation and demonstrate their remarkable potential for various activities: anti-aging, anti-inflammatory, antioxidant, reshaping, firming, moisturizing, skin protection properties and so on. While it is still an evolving area that requires further research, microalgae also exhibit potential across various sectors, including the pharmaceutical industry, the wastewater treatment sector, the field of biofertilizers, and the biomaterials industry. Overall, the diverse applications of microalgae highlight their potential to contribute to a more sustainable and healthier future.
The SCALE Project’s Role in Unlocking the Full Potential of Microalgae
Although microalgae offer numerous benefits, their cultivation is a relatively new field, and further research and development are needed to fully harness their potential. Currently, there are only a handful of species being produced on a large scale for various industries, and there is no industrial production site that efficiently utilizes the exceptional biodiversity of microalgae that are readily available to transform them into natural ingredients. However, the SCALE project aims to address this gap by building and operating a the first-fully integrated biorefinery that utilizes the untapped diversity of microalgae to produce high-value ingredients for the food, food supplements, feed, and cosmetics sectors. This initiative aims to establish economically-sound and environmentally-friendly processes to promote the use of microalgae in various industries. To achieve this goal, the SCALE project gathers 11 key EU and international partners in an integrated value chain from microalgae production to high value ingredients extraction of bioactives compounds and end-use applications in food, food supplements, feed, and cosmetic domains.
Click here to discover the SCALE project presentation in video.
Would you be interested in exploring additional information on microalgae?
Here are some articles for you :
- Exceptional microalgae: 3 questions about Phaeodactylum tricornutum
- Tisochrysis lutea, a golden Tahitian microalgae with beneficial properties
- Porphyridium cruentum: 5 amazing properties of this remarkable microalgae attractive for the cosmetic
- The upscale and exploration of new high-value ingredients from microalgae
Sources :
- https://microphyt.eu/nutrition-well-being-the-power-of-microalgae/
- https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-018-0879-x#Sec22
- https://www.pro-future.eu/news/microalgae-what-are-they-and-how-to-grow-and-use-them
- https://www.linkedin.com/posts/dr-ambika-h-d-809783a9_biotechnology-environmental-foodactivity7032254775916158976Hh5Y?utm_source=share&utm_medium=member_desktop
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Join us this fall 23! 🍂
During this Fall season 2023, from North America to Europe, Microphyt will take part in several professional events of great importance for the nutraceutical, cosmetic, microalgae, and bioeconomy industries. We hope to meet you there and share with you about our unique ingredients extracted from microalgae and the related bioeconomy industry. Do not hesitate to join us for these occasions:
October 5-7th: First-ever EU Algae Awareness Summit – Microphyt and its CBE JU Flagship SCALE project will take part of this first-ever European Algae Summit as one of the most important players in the algae industry. Co-hosted by the European Commission, the French Government, and the Global Seaweed Coalition, the summit will kick off a process of raising awareness among EU Member States’ administrations and the public about the many benefits of algae to national and regional economies, to people, and to the regeneration of our Ocean. Julie Person (project coordinator and corporate communication) will be present to take part of the discussions. Our first samples of finished cosmetic and nutraceutical products based on microalgae will be showcased at the exhibition. October 7th is a day open to general public don’t miss this unique opportunity to discover the wonderful world of microalgae and seaweeds.
More information here , with links to follow the summit broadcast
Location: France, Paris, La maison de l’Océan
October 24-25th: European Forum for Industrial Biotechnology & the Bioeconomy 2023, EFIB’23 – EFIB is Europe’s primary conference dedicated to the economic and green contribution to Europe from innovation and manufacture within industrial biotechnology and the bioeconomy. This event gathers a community of researchers, policy makers, regulators, & global organisations. Microphyt and its SCALE project team will take part of this Europe’s leading event with the presence of Julie Person (Project coordinator and corporate communication). A session will be dedicated to the biomanufacturing & Europe’s Industrial Transformation on Oct 25th, and Julie will speak about our CBE JU Flagship SCALE project. You could also come and visit us on SCALE booth hosted by our partner Bioeconomy for Change, we will be happy to talk with you about our activities and Microalgae-based economy! Do not hesitate to make an appointment.
Location: The Netherlands, Rotterdam, De Doelen ICC
October 25-26th: Supply Side West – Microphyt nutraceutical team will be exhibitor at international tradeshow dedicated to nutrition and food supplement. Book in advance your meeting with our team and visit our booth 4442. Vincent Usache (CEO), Christel Lemaire (Marketing Manager Nutraceutical ingredients), and Thibault Fesquet (Business developer) will be there to exchange and introduce you our new ingredient designed to naturally support weight management and healthy lifestyle efforts.
Location: United-States, Las Vegas, Mandaly Bay Convention Center
Book a meeting: contact@microphyt.eu
October 25-27th: SEPAWA Congress – Laura Bertrand (Cosmetic business developer), will take part in this specialized congress and exhibition for the detergents, cleaners, cosmetics and fragrances industry organized by DGK (Cosmetic Science Conference). She will be delighted to explain in more detail our poster #44 on “neuro-soothing effect on Tisochrysis lutea on co-culture of sensory neurons and keratinocytes” related to our Luteana Ingredient and exchange with you about our microalgae-based ingredients portfolio !
Location: Germany, Berlin, Estrel Congress Center Berlin
Book a meeting: contact@microphyt.eu
November 11-15th: Neuroscience 2023 – Jonathan Maury (Clinical research manager) will take part in this unrivaled scientific program with the presentation of new clinical results related to our nutraceutical Brainphyt ingredient designed to naturally support cognitive function and stress management -Don’t miss the presentation of poster #PSTR393.10 during the session entitled: Consequences of Diet, Exercise or Environment on November 14th at 2pm.
Location: USA, Washington D.C., Walter E. Washington Convention Center
December 6-7th : First CBE JU Stakeholder Forum – Microphyt and its SCALE project partners will take part of the conversation about ‘What next for the European bio-based sector?’ among 600 stakeholders. Julie Person (Project coordinator and corporate communication) will be present to share the experience of our CBE-JU flagship SCALE project in terms of “achieving financial success in the bio-based sector”. Our first samples of finished cosmetic and nutraceutical products based on microalgae will be showcased at the exhibition. Do not hesitate to make an appointment.
More information here – Registrations for the event here
Location: Belgium, Brussels, The EGG Congress & Meeting Center
December 12-15th : ALGAEUROPE – For the second year, Microphyt is gold sponsor of this europe’s leading algae event co-organized by the EABA and DLG Benelux. Indeed, it is one of the most global comprehensive conferences about science, technology and business in the Algae Biomass sector organized by industry professionals. Come and visit us at our Table Show 10 (floor 1), to exchange about microalgae-based ingredients, our CBE JU Flagship SCALE project, don’t miss the 10-min speech planned during conferences. Several Microphyt team members from R&D, Production & Julie Person (Project coordinator and corporate communication) will be there to welcome you! Do not hesitate to make an appointment.
Location: Czech Republic, Prague, Grandior Hotel Prague
Book a meeting: contact@microphyt.eu
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
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SCALE project wins the CBE impact 2023 photo competition
SCALE project, with Microphyt Camargue technology, won the prestigious « CBE impact 2023 » photo competition in the « Biobased production processes » category. Organized by the Circular Bio-based Europe Joint Undertaking (CBE JU), this competition showcased the remarkable impacts of 20 projects, both ongoing and completed, funded by the public-private partnership. Through the submission of high-quality photos and videos in seven distinct categories, the participants effectively conveyed the essence and significance of their initiatives.
A total of 95 visuals were submitted by the participants for the first five categories, highlighting specific aspects such as the projects’ impact and their diverse applications. The sixth category was dedicated to short videos, while the winners of the seventh category was determined by a vote from the CBE JU community on LinkedIn.
To evaluate the entries, the competition jury, composed of experts from the European Commission, the Bio-Based Industries Consortium (BIC), and the CBE JU Program Office, meticulously considered criteria pertaining to the projects’ connection with CBE JU, as well as the creativity, quality, and composition of the images.
The award-winning photo from the SCALE project highlights the cutting-edge CAMARGUE photobioreactor technology developed and patented by Microphyt, located in Baillargues, France. This innovative technology is up-scaled during the project to produce 100 tons of high-value ingredients for nutraceuticals and cosmetics and plays a pivotal role in advancing biobased production processes, thereby unveiling exciting new horizons in these fields.
In recognition of their outstanding achievement, the winners of the competition, has been cordially invited by CBE JU to attend the European Forum for Industrial Biotechnology (EFIB) conference taking place in Rotterdam on 24-25 October 2023. This prestigious conference provides an unparalleled platform for presenting their groundbreaking projects, fostering exchanges of ideas, and further stimulate innovation within the field of biotechnology. As project coordinator, Microphyt will speak there about SCALE project.
Thanks to their success in the « CBE impact 2023 » photo competition, SCALE and the otherco-funded CBE Projects continue to demonstrate their commitment to the development of sustainable and bio-based solutions, which are essential to meet current environmental and economic challenges.
Congratulation to all the CBE-JU photo competition winners, and especially internally to Emmie, Manon and Clément from our R&D team for this great picture of our bio-based technology.
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Boost your cognitive skills: find out more about the GamePhyt clinical trial!
- Optimizing cognitive abilities: a top priority for consumers
With our increasingly active lifestyles, many of us are keen to optimize our cognitive abilities in order to perform all kinds of tasks efficiently throughout the day. For example, a student needs energy and concentration for a day of revision. As do young professionals, who are under intense stress to achieve their daily goals. Other precision professions, such as pilots or armed forces, also need to maintain high cognitive skills so that they can react quickly, making the right decisions for many obvious reasons.
Today, it’s a fact that the vast majority of the population, often subjected to periods of stress and intense mental fatigue, need to be at the peak of their cognitive abilities: intense concentration, vigilance, optimized reaction time for good decision-making, etc.
- A solution for boosting cognitive capacity
Microphyt has developed a natural ingredient which is effective on many parameters of the cognitive sphere. This ingredient is based on Microphyt’s flagship microalgae, Phaeodactylum tricornutum, and guarana, which are renowned for their fucoxanthin and guaranine content respectively. Fucoxanthin is a strong antioxidant with brain benefits. It can improve cognitive function by promoting memory, attention and reasoning ability. It also helps to protect brain cells against damage and aging. Guaranine, for its part, provides prolonged energy, improving concentration and alertness.
- Gamephyt: a clinical study to demonstrate its properties.
Microphyt created Gamephyt™ by combining fucoxanthin from Phaeodactylum tricornutum and guaranine from guarana. To validate the benefits of GamePhyt™ on cognitive abilities, a clinical study was carried out with experienced gamers, who are subjected to intense stress and mental fatigue. In collaboration with Texas A&M University, Microphyt carry out a double-blind study with one placebo group and two groups receiving different doses of the microalgae extract. The results showed that GamePhyt™ improved players’ accuracy, reaction time, concentration, decision-making, execution speed and mental energy, all in just 15 minutes! GamePhyt™ was also shown to help maintain good mood, visual comfort and sleep quality, with no observed side effects.
- A study applicable to the entire population
In addition to improving the already high baseline cognitive performance of gamers, this promising study suggests that the application of Gamephyt™ could be extended to the entire population, from students and office workers to F1 drivers, athletes and many others! GamePhyt™ represents a natural and effective solution for anyone who may be subject to periods of stress and needs to boost their cognitive abilities quickly.
Find out more about the clinical study: https://www.mdpi.com/2072-6643/15/8/1918
- Abdul Hannan, et al., 2020, Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances
- MINGHETTI et al., 2014, Nonenzymatic oxygenated metabolites of α-linolenic acid B1- and L1-phytoprostanes protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte
- Alghazwi et al., 2019, In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation
- OTA, et al., 2019
- FERNANDO, et al., 2015
- REBELLO, et al., 2015
- Efficacy of omega-3 PUFAs in depression: A meta-analysis, Transl Psychiatry 2019; 9: 190.
- Rhonda P., Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior, 2015
- PALANICHAMY et al., 2020, “Influence of Esports on stress: A systematic review”, Ind Psychiatry J. 2020 Jul-Dec; 29(2): 191–199
In the meantime, if you have any questions or you’d like more information, please don’t hesitate to contact us by e-mail at contact@microphyt.eu or by clicking here.
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Spring is here, join us! ☀ 🌸
From Asia to North America and Europe, Microphyt will take part in several professional events of great importance for the cosmetic and nutraceutical industries during this beautiful Spring season 2023 ! We hope to meet you there and exchange with you. Do not hesitate to join us for these occasions :
- April 19th and 20th : European Algae Industry Summit – Microphyt will participate in this congress which will gather the main actors of the algae industry in the world (cosmetics, human and animal food, biomaterials, nutraceuticals and pharmaceutical products). Christel Lemaire, (Marketing Manager Nutraceutical ingredients) will hold a presentation on the subject : Microalgae in food, the European consumers perception 🍃
More information here : https://www.wplgroup.com/aci/event/european-algae-industry-summit/
Location : Portugal, Lisbon
- May 2-3 : NYSCC Supplier Days – We will be exhibiting in New York City at North America’s largest event dedicated to ingredients, raw materials and formulation technologies for cosmetics and personal care. You can already contact us to schedule an appointment or come directly to our booth #229 that we share with OnScent, our US distributor. Clementine Depresle, (Cosmetic Product Manager) and Ilya Zhivkovich, (Chief Business Officer), will be present to present our new anti-aging active PhycoAge™
Booking an appointment : contact@microphyt.eu
More information here : https://nyscc.org/suppliers-day/
Location : United States, New York City, the Jacob K. Javits Convention Center, booth #229
- From 9 to 11 May : Vitafoods Europe – This year again we will participate in this exhibition, the international event of nutraceutics! It is the ideal place to meet suppliers of raw materials and innovative actives for food supplements like Microphyt ! Come and visit us at our booth #J142 on the French pavilion where Vincent Usache (CEO), Jeremy Moore (Sales Director), Christel Lemaire (Marketing Manager Nutraceutical ingredients), Lucie Giraud (Nutraceutical Application Manager), Julie Person (Project Coordinator and Corporate Communication) and Frank Mazars (Assistant Product Manager) will be present to discuss with you.
Booking an appointment : contact@microphyt.eu
More information here : https://www.vitafoods.eu.com/en/home.html
Location : Switzerland, Geneva, Palexpo, booth #J142
- May 16 : Hello La Tech – The flagship event of the French Tech Mediterranean! Julie Person, (Project Coordinator and Corporate Communication), will be on Microphyt booth to present the company and its innovations.
More information here : https://hellolatech.lafrenchtechmed.com/fr
Location : France, Montpellier, Mo.Co. Art Exhibition Museum
- From 17 to 19 May : CITE Japan – First participation of Microphyt to this exhibition organized by the Japanese association of cosmetic ingredients! You can contact us to schedule an appointment or come directly to our booth #N10-30 that we share with IMCD Japan, our Japanese distributor, Cyrielle Houdin, (Cosmetic Marketing Manager) will be present to discuss our innovations.
Booking an appointment : contact@microphyt.eu
More information here : https://www.citejapan.info/en/index.html
Place : Japan, Yokohama, Pacifico Yokohama, booth #N10-30
- May 23-25 : BIOKET North America – This is the global conference dedicated to biomass processes and technologies! Julie Person (Project Coordinator and Corporate Communication) will hold a conference on May 23 during the “Breakout sessions dedicated to KETs”. The theme of her presentation will be “SCALE : the first of its kind fully integrated microalgae biorefinery at an industrial scale.”
More information here : https://bioket-2023.b2match.io/
Location : Canada, Trois-Rivières (QC), CECi TROIS-RIVIÈRES
- May 24 and 25 : Cosm’Innov – The international scientific congress for cosmetic research will take place and Clémence Thébaud (Product Development Manager) will present a poster on Renouvellance™, our biomimetic active against urban photostress.
More information here : https://www.cosm-innov.com/
Location : France, Orléans, CO’Met – Orléans Convention Center
- June 7-9 : Nutriform Business Days – This international congress is dedicated to food supplements and nutrition. It is an opportunity to learn more about the latest market trends and to meet professionals from the nutraceutical industry. For this 7th edition of Nutriform Business Days, Christel Lemaire (Marketing Manager for nutraceutical ingredients), and Vincent Usache (CEO) will be present to exchange with you during these 3 days of congress.
More information here : https://www.nfbd.fr/
Location : France, Antibes, Palais des Congrès
- From 13 to 15 June : Plant Based Summit – Microphyt will participate in this international event for the bioeconomy with the presence of Julie Person (Project Coordinator and corporate communication). A session will be dedicated to the theme : “A new nutrition : flavors and adjuvants, as a complement to the food industry”, and Julie will make you discover our product Gamephyt™.
You will find also the SCALE project, the flagship supported by the BBI-JU and led by Microphyt, with a dedicated booth where Julie will be present to answer your questions, do not hesitate to make an appointment.
More information here : https://www.plantbasedsummit.com/
Location : France, Lille, Grand Palais
- June 15-17 : ISSN – Jonathan Maury (Clinical Study manager), will present an exclusive preview of 2 scientifics posters presenting the results of 1/ our latest preclinical study and 2/ the data from a clinical study conducted with Texas A&M University on our 2 upcoming nutraceutical ingredients. Come and see him and he will answer your questions! Launch of the first ingredient planned for October, during SupplySide West 2023, in Las Vegas!
More information here : https://www.sportsnutritionsociety.org/
Location : United States, Fort Lauderdale, Westin Fort Lauderdale Beach Resort
- From 12 to 14 July : In Cosmetics Korea – Microphyt will take part for the first time in the only exhibition dedicated to ingredients for cosmetic products in Korea. Cyrielle Houdin (Cosmetic Marketing Manager) and Ilya Zhivkovich, (Chief Business Officer), will be present and exhibiting on the “Natural zone extract” at booth P19. Do not hesitate to come and see them on the show or by making an appointment before : contact@microphyt.eu
More information here : https://www.in-cosmetics.com/korea/en-gb.html
Location : South Korea, Seoul, Coex, booth P19
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
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Exceptional microalgae: 3 questions about Phaeodactylum tricornutum
Why is Microphyt interested in the Phaeodactylum tricornutum microalgae?
Microphyt’s experts work on ingredients with high added value derived from microalgae for the cosmetics and nutraceutical industries and Phaeodactylum tricornutum boasts some particularly rare qualities.
Its composition is rich in active compounds and, depending on the extraction method used, we can obtain molecules with different properties. For example, the oily extract is teeming with fucoxanthin, a carotenoid renowned for its anti-oxidant, skin-protective and neuroprotective properties. It also contains numerous fatty acids, such as omega-3s, EPA and DHA, and sterols.
The aqueous extract, for its part, is rich in silicium, because Phaeodactylum tricornutum is known for its ability to capture and transform the inorganic silicium found in its living environment into organic silicium, which can be assimilated by the human body. This trace element is extremely helpful when it comes to restructuring and protecting the skin.
Why is Phaeodactylum tricornutum a reference for scientists?
Phaeodactylum tricornutum is a marine diatom. Scientists regard it as an observation model, in order to understand the metabolism and evolution of this family of microalgae. It also happens to be the second marine diatom whose genome has been fully sequenced. Its polymorphic nature, depending on its environmental conditions, is absolutely remarkable. It can exist in different morphotypes: oval, fusiform and triradiate (or tricornate, hence its name). This adaptive morphology is possible thanks to its biofunctional silica wall, reflecting strong dynamism and great plasticity.
P. tricornutum’s morphotypes How does Microphyt harness the benefits of Phaeodactylum tricornutum?
Microphyt is very familiar with P. tricornutum as it has been using its technology to cultivate this diatom in a controlled environment on an industrial scale for several years in order to meet the needs of cosmetics and nutraceutical professionals.
This microalgae has given rise to two active ingredients that can be used in dietary supplement formulas: the first ingredient BrainPhyt™, helps prevent cognitive decline, the second ingredient GamePhyt™ optimizes cognitive performance in e-gamers.
Our teams recently explored the marine silicium produced by P. tricornutum. Marine silicium enables the diatom to build an external wall which protects it against aggressions and regulates interactions with its environment. Microphyt managed to extract this silicium to create PhycoSi™, a cosmetic active ingredient which acts at the surface and deep down to restore skin.
Special characteristics of microalgae diatoms
Although they have existed on earth since the Mesozoic era, 190 million years ago, they were not discovered until the 19th century. These marine microalgae can be found along several coastlines in Europe, America and East Asia. These single-cell eukaryotic organisms with silica walls are also the main generators of O2 in oceans. Another characteristic feature of diatoms is that they have genes derived from green and red algae.
They are therefore at the crossroads between the living world and the inorganic realm.
Bibliography:
Lourenço-Lopes, C et al. Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries. Trends in Food Science and Technology, 117 : 163-181 (2021)
Butler t, et al. Phaeodactylum tricornutum: a diatom cell factory. Trends in Biotechnology (2020)
Rastogi, A., Vieira, F.R.J., Deton-Cabanillas, AF. et al. A genomics approach reveals the global genetic polymorphism, structure, and functional diversity of ten accessions of the marine model diatom Phaeodactylum tricornutum. ISME J 14, 347–363 (2020).
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Microphyt Appoints Two New Directors and Confirms its Focus on Sustainable Value Creation with a New ESG Advisory Committee
- Two New Directors, Hilde Windels[1] & Anne Colonna[2], are joining Microphyt’s Board,
following a successful €15 million financing round. - Chloé Schiaffino from Bpifrance is leading the newly formed ESG Advisory Committee.
- Hilde Windels is leading the newly formed Risk and Audit Committee.
Baillargues (France), March 24th, 2023 – Microphyt, a leading innovation-driven company in microalgae-based natural solutions, for nutrition and well-being announces the appointment of Anne Colonna (representing BOLD) and Hilde Windels BV as new Directors of Microphyt’s Board. Following its most recent financing of €15 million (November 2022), Microphyt is accelerating both new product development and commercialization of its ingredient portfolio. To meet customer demand, Microphyt is also increasing the production capacity of its industrial platform in Baillargues (South of France).
Hilde Windels BV is appointed as an independent Director to lead the Risk and Audit Committee. Hilde has a track record as CFO, CEO and Director in supporting companies during the transition from early stage through scale-up. She has historically been focused on enabling substantial value creation through the commercialization of proprietary technology and products. “I’m delighted to lead the Audit and Risk Committee of Microphyt’s Board of Directors at this particular time in its development’ stated Hilde Windels. “Microphyt has effectively shown that it can successfully produce and sell natural bioactive ingredients in nutrition and personal care markets globally. Consolidating all these building blocks and aligning with the expectations of our stakeholders, including our long-term financial investors, is a journey I am very excited about.”
Anne Colonna, General Manager Advanced Research at the L’OREAL Groupe is representing BOLD Business Opportunities for L’Oréal Development, L’OREAL’s corporate venture fund. Anne brings her deep expertise in the research and the development of sustainable solutions and responsible innovations in well-being.
To reinforce its focus on sustainability, Microphyt has decided to form an ESG Committee. Led by Chloé Schiaffino from Bpifrance, one of Microphyt’s lead investors. The ESG Committee will advise the Board to further advance Microphyt’s CSR initiatives. Chloé Schiaffino explained “Microphyt has been a pioneer in fostering the massive transition towards natural and sustainably produced solutions in nutrition and wellbeing. I am particularly thrilled to help expand the initial commitment of Microphyt’s CEO Vincent Usache in the Corporate Social Responsibility with the actions of the ESG Committee.”
Lieven De Smedt, Chairman of the Board of Microphyt, added: “Having Anne, Chloé and Hilde on board in their new roles will not only complete the skills and competencies on our Board, but given their complimentary ways of looking at things, will enhance our strategic decision making. If Microphyt is already in the top league of bringing inspiring Natural Ingredients to the market, this Board and the new ESG Committee are committed to become a top league player in Sustainable Value Creation.
To read more about Microphyt’s Board, click here.
To download the Press Release, click here.
[1] representing Hilde Windels BV
[2] representing BOLD (Business Opportunities for L’Oréal Development)
- Two New Directors, Hilde Windels[1] & Anne Colonna[2], are joining Microphyt’s Board,
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An innovative solution to prevent skin aging by acting simultaneously on the various skin layers
With age, our skin loses its structure and firmness. This natural aging process can be slowed down thanks to innovative ingredients, such as PhycoSi™, which acts deep down and at the surface.
Skin is a complex, multi-layer tissue
The three main skin layers, the epidermis, dermis and hypodermis, are constantly moving and interacting.
- The top layer, the epidermis, protects against external aggressions.
- The intermediate layer, the dermis, maintains the skin’s structure and hydration level.
- The bottom layer, the hypodermis, stores energy and has an endocrine function.
The dermis plays a partial role in the skin’s firmness and elasticity as it contains an extra-cellular matrix (3D network of complex molecules) which is responsible for the skin’s biomechanical properties.
The causes and effects of skin aging
Skin aging depends on two main factors:
- Intrinsic aging: linked to an individual’s physiology and genetic characteristics. It occurs naturally and gradually from the age of 30 onwards.
- Extrinsic aging: linked to an individual’s lifestyle and environment (exposure to UV, pollution, tobacco, diet, etc.). These factors visibly speed up premature aging.
Under their influence, the skin gradually loses its thickness at the dermis and the epidermis, revealing the first fine lines and wrinkles. Extracellular matrix synthesis also slows down, leading to a loss in elasticity and firmness.
PhycoSi™: the dual-action solution to regenerate the skin
Microphyt has designed an active ingredient, PhycoSi™, composed of organic marine silicium (news article available) which can act both deep down and at the skin’s surface.
Just 14 days after applying this active ingredient, we can see that the dermis is recharged and restructured deep down. The measured increase in AQP3 (microchannels that circulate water, glycerol and urea) in fibroblasts helps to boost cell exchanges. The densified dermis thus regains its biomechanical properties for more elastic and toned skin.
The effectiveness of PhycoSi™ is visible on the top layer of skin after 28 days. By improving the epidermis’ impermeability to external agents, the skin barrier is strengthened. Clinical results show evidence of regenerated skin thanks to a gentle exfoliation method. Wrinkles and fine lines are reduced and the skin becomes smoother.
To find out more about our new active ingredient, PhycoSi™, click here.
Bibliography:
Marie-Paule Jacob, extracellular ageing and vascular ageing. Med Sci (Paris) 2006; 22 : 273–278
A J Bailey, molecular mechanism of ageing in connective tissues. Mech Ageing Dev 2001; 122(7):735-55
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A new perspective on marine silicium, an essential trace element for the skin
Silicium, an essential trace element for maintaining structures, is present in microalgae diatoms and in the skin. Thanks to its extensive R&D efforts, Microphyt has managed to extract this element in a manufacturing co-product to create PhycoSi™, an upcycled bioactive ingredient containing bioavailable marine silicium. We take a closer look at a new way of harnessing the benefits of silicium transformed by the magic of microalgae.
Silicium on the trace elements podium
In chemistry terms, silicium is a metalloid. In biology terms, it is a trace element which is crucial for the proper functioning of the human body. After iron and zinc, silicium is the third trace element in the human body, mainly found in bones, blood vessels and the skin.
Silicium’s benefits for the skin
Silicium is most abundant in connective tissue, such as the skin. As well as playing a metabolic and structural role in the synthesis and stabilization of collagen in the dermis, it also helps to maintain a good level of hydration.
Cosmetics professionals particularly appreciate it for its virtues against skin aging. Clinical trials conducted by Microphyt demonstrated that PhycoSi™, the first upcycled active ingredient rich in bioavailable marine silicium, recharges and restructures the dermis deep down, then protects and restores the skin’s surface. This two-step action smooths the cutaneous microrelief and increases dermis density.
Marine silicium, an eco-friendly solution
Silicium is the second most abundant element in the earth’s crust after oxygen, and yet it is hard to find on the earth’s surface.
In nature, silicium exists in two forms:
- One that cannot be assimilated by the human body (amorphous silica in sand or mineral silica in quartz and cristobalite).
- And one which can be assimilated by the human body and accounts for just 0.03% of the biota (silicon dioxide synthesized by living organisms such as microalgae).
In the cosmetics sector, silicium is traditionally sourced from plants such as bamboo, which absorbs silica through its roots to improve its rigidity. However, this industrial process involves combustion, which changes the structure (and thus the beneficial effect) and emits greenhouse gases, which are harmful to the environment.
Marine silicium is therefore the most environmentally friendly alternative. As a result of soil sedimentation, silica can be found in rivers and oceans, much to the delight of diatoms (a type of microalgae). The latter naturally transform this inorganic silicium into organic silicium to create their very own protective barrier against the external environment. As such, diatoms are a sustainable source of assimilable silicium.
PhycoSi™, Microphyt’s latest silicium-based cosmetic active ingredient
Thanks to an ingenious solution, Microphyt managed to upcycle a manufacturing co-product from a nutraceutical ingredient that was previously unused.
By creating a new extraction process on this co-product, Microphyt obtains an upcycled bioactive and bioavailable ingredient for the skin that is rich in marine silicium.
This new upcycling technique strengthens Microphyt’s CSR position and opens up new opportunities for new effective and sustainable ingredients.
To find out more about our new active ingredient, PhycoSi™, click here.
Bibliography :
Quignard, S et al. Silica nanoparticles as sources of silicic acid favoring wound healing in vitro.Colloids and Surfaces Biointerfaces 2017, 155:530-537
Picaud, C. Oligo-éléments : excès, carences et conseil officinal 2017. Université de Limoges.
Jean-Dominique Meunier, Le rôle des plantes dans le transfert du silicium à la surface des continents, Comptes Rendus Geoscience, Volume 335, Issue 16, 2003, Pages 1199-1206, ISSN 1631-0713. -
Join us this winter 23!❄
As a continuation of 2021 and 2022, Microphyt will be present at several unavoidable cosmetic and nutraceutic events. We will be delighted to meet you and exchange. Come and join us to these various events:
January 9-11th: 10th annual world congress of ocean – Vincent Usache, Microphyt’s CEO will be present at this international congress on the marine environment to present Microphyt and all the potential that microalgae can bring to the design of bioactive ingredients in the cosmetic and nutraceutic field.
Place: Japan, Sapporo
Book a meeting : contact@microphyt.eu
January 10-11th: Cosmet’Agora – 2023 starts strong for cosmetic team which will exhibit to Cosmet’Agora. This French cosmetic trade show organized by the SFC, celebrates it’s 15th edition this year. It will be the occasion for the cosmetic team to introduce its last launch PhycoSi™ on the French market. We will be also formulation award contender to highlight our skills for cosmetic application with our actives.
Place: France, Paris, Champerret Center
Booth : 46
Book a meeting : contact@microphyt.eu
January 24th: Scientific workshop on marine PUFA – In collaboration with our scientific partner IBMM (Institut des Biomolécules Max Mousseron), Microphyt is co-organising this scientific day on polyunsaturated fatty acids (PUFA) from the marine world. This is an opportunity for Microphyt to present its scientific advances in this field.
See the program here, do not hesitate to contact us: contact@microphyt.eu
February 15-17th: Sports and Active Nutrition Summit USA – For this unmissable event in the field of sports nutrition, Christel Lemaire, marketing manager nutraceutical ingredients and Ilya Zhivkovitch Chief business officer, will represent Microphyt as a Gold Sponsor. The opportunity to promote GamePhyt™, our nutraceutical ingredient intended for e-gamers.
Place : United-States, San Diego, Hyatt Regency Mission Bay
Book a meeting : contact@microphyt.eu
March 28-30th: In Cosmetics Global – Microphyt will exhibit on in-cosmetics global event, the leading global event for personal care ingredients. Book appointments with our team in advance and visit us our booth on the French pavilion.
Place : Spain, Barcelona, Fira Barcelone – Gran Via
Booth: French Pavilion, n°X84
Book a meeting: contact@microphyt.eu
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
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Microphyt experts: Antoine Delbrut, Head of the Extraction Unit
Antoine Delbrut is one of the world’s few specialists in microalgae production and extraction. And what’s more, he has the know-how to transform biomass into quality ingredients. Antoine started as an intern but soon rose up through the ranks at Microphyt – reflecting the company’s own meteoric rise. We find out more about his unique expertise.
Less than ten years ago, you joined Microphyt when you finished your studies. You’re now coordinating the production of a dozen different ingredients. What an amazing journey!
My career development has been based on trust and knowledge sharing – a win-win approach. Microphyt gave me the freedom to experiment and to be in close contact with clients, without any barriers. It seemed logical to me to continue my PhD and my research with the company. The aim was to explore new culture techniques and extraction processes with a pool of microalgae that are rich in fucoxanthin and polyunsaturated fatty acids. It was in some ways a prelude to the research that led to Brainphyt, a unique ingredient aimed at maintaining cognitive function.
You were able to develop your own career in step with Microphyt’s rapid growth.
We grew together, relatively quickly. In 2014, Microphyt was a very small business with huge potential. Today it is recognized worldwide as a leader in converting microalgal biomass into high value-added ingredients. We have grown from eight employees to around fifty. The five photobioreactors that were there when I arrived will soon be replaced by the world’s first microalgae biorefinery. The size and production capacity of the extraction plant will increase tenfold to reach an annual production level of dozens of tons of cosmetic and nutraceutical ingredients.
Extraction is a very strategic stage. How do you guarantee production quality?
One challenge is to adapt new processes to industrial scale while still complying with quality and hygiene standards, which we are very strict about. We need to have detailed operating procedures to guarantee repeatable, quality production so that we can deliver ingredients to our clients in good time. We are juggling with around a dozen “routine” production processes and three to five new processes that are developed each year. One of Microphyt’s trademarks is that it is constantly innovating.
What qualities do you need for your job?
Firstly flexibility, to be able to integrate real-world requirements and pressures into production schedules. We are constantly adapting. Another essential quality is versatility, to deal with extremely varied tasks. My job requires knowledge in industrial equipment, biochemistry, logistics, and calculating manufacturing cost prices. And of course I need to be attentive both to the teams, because we are in constant dialog and interaction, and to the machines and production data, to improve processes and anticipate problems.
Antoine Delbrut, Head of the Extraction Unit – Copyright Microphyt Education and training of Antoine Delbrut, Head of the Microphyt Extraction Unit
- PhD with a dissertation entitled “Study of the coupled production and extraction of carotenoids and polyunsaturated fatty acids from microalgae”
- Master’s in plant biology and biotechnology
- Vocational Bachelor’s (licence professionnelle) on genetic improvements in plants
- Technical diploma (DUT) in biological engineering
The favorite microalga of Antoine Delbrut, Head of the Microphyt Extraction Unit
Phaeodactylum tricornutum: it’s an entire microfactory within a single microalga for the benefit of our health! This unique marine diatom adapts to different culture conditions, grows rapidly and can transform into three distinct forms.
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Microphyt raises €15 million to accelerate the commercialization of its microalgae-based natural solutions for nutrition and well-being
- Microphyt’s Series B fundraising will allow to accelerate the global marketing of its clinically-approved range of Natural Ingredients for nutrition and cosmetic markets.
- The round was both supported by L’Oréal through its venture capital fund BOLD Business Opportunities for L’Oréal Development and by the Microphyt’s current investors, including Bpifrance, through its SPI Fund, and Sofinnova Partners.
CAMARGUE Photobiorectors – Copyright Microphyt Baillargues (France), November 29th, 2022 – As part of its global strategy; Microphyt, a leading company in microalgae-based natural solutions for nutrition and well-being, announced a Serie B fundraising of €15 million. This investment was led by L’Oréal through its venture capital fund BOLD Business Opportunities for L’Oréal Development and supported by Microphyt’s current investors Bpifrance, through the “Sociétés de Projets Industriels” fund (“SPI fund”), Sofinnova Partners, IXO-Private Equity, Supernova Partners, IRDI and Sofilaro. The funds will be used to accelerate both the new products development and the commercialization of the product portfolio as well as to increase production of Microphyt’s industrial platform in Baillargues (South of France) to meet customer demand.
In nutrition and wellbeing, consumer demand for natural, effective, safe and sustainably produced solutions is booming. The world market for ingredients for these markets, represents more than US$ 70 billion with a share of natural ingredients (US$ 5 billion) that shows the strongest growth (8% per year). Among the natural ingredients, natural microalgae are most suited to meet consumer expectations thanks to their diversity and the quality of the bioactives.
Microphyt launched successfully over the last 18 months 5 new proprietary ingredients, supported by scientific evidence. In Advanced Beauty, cosmetic actives ingredients like Renouvellance™, Luteana™ and Phycosi™ are increasingly used by cosmetic brands worldwide. In Novel Nutrition, Microphyt launched this month the only clinically-validated natural ingredient specifically designed for e-gamers in the dietary supplement market in the US, Gamephyt™, as well as Brainphyt™ a new ingredient that improves the well-being of the elderlies.
In addition of its own development roadmap, Microphyt will partner with L’Oréal to develop and produce specific microalgae-based solutions for cosmetics, hence contributing to L’Oréal’s corporate objective that 95% of its ingredients will be bio-sourced, derived from abundant minerals or from circular processes by 2030.
“This Series B is again a major milestone in our development and we are pleased that a strategic investor like L’Oréal share the ambition to accelerate the transition to a more sustainable beauty. In addition, we are thankful that our existing investors such as Bpifrance, Sofinnova Partners or IXO PE continue to support our strategy to unlocking the full potential of microalgae amazing diversity through our unique technology platform. With this funding, we will speed up the development and supply of novel natural products that solve the key challenges of Nutrition & Well-being” stated Vincent Usache, CEO at Microphyt.
This new partnership with Microphyt enables us to further accelerate our drive towards more sustainable beauty, in line with L’Oréal R&I Green Sciences approach, explained Anne Colonna, General Manager Advanced Research, L’Oréal. Our ambition with Microphyt is to collectively develop responsible innovations on a large scale and make them available to as many people as possible.
Jean Philippe Richard, Deputy Director of SPI fund from Bpifrance, explained: “We welcome the investment led by L’Oréal through its venture capital fund BOLD as a great opportunity for Microphyt to accelerate its development. It confirms its growth potential based on the responsible use of marine biodiversity for its cosmetic and nutraceutical customers. The operation also testifies to the fact that a controlled industrial and R&D strategy based on biotechnology is key to ensuring the success of an industrial start-up supplying bio-based, traceable and low carbon-impact products.”
Michael Krel, Partner at Sofinnova Partners, said: “Microphyt is one of the rare companies in the sector who have been able to reach a level of commercial and industrial maturity enabling them to deliver on the promise of industrial biotechnology: Products and platforms that offer more sustainable, bio-based solutions for nutrition and wellness. This milestone signals a major turning point in the company’s development and we are honored to have been part of it from the beginning.”
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Discover GamePhyt™, the first 100% natural bioactive complex from Microphyt, specifically designed for gamers
The results of the clinical trial for new ingredient GamePhyt™ are out: they are outstanding and extremely promising! Microphyt will unveil the full study at the international SupplySide West show in November 2022 in Las Vegas.
Devoted gamers and all those looking to improve their powers of concentration have something to get excited about! The results of the clinical trials for the new ingredient GamePhyt™ are out, and they are outstanding and extremely promising. Microphyt will unveil the full study at the international SupplySide West show in November 2022 in Las Vegas. In the meantime, here’s a sneak preview of the first findings.
With the development of GamePhyt™, a new ingredient that meets very specific consumer needs, Microphyt is continuing its rise to global leadership in the production of natural active ingredients derived from microalgae.
GamePhyt™ is a unique patented combination, the culmination of three years of research.
Improved reaction time and concentration – naturally and with no side effects
GamePhyt™ harnesses the synergies between the outstanding qualities of fucoxanthin-rich microalgae and the benefits of guarana, which contains guaranine. The extract of Phaeodactylum tricornutum microalgae acts to improve cognitive functions such as memory and ease of learning and also reduces stress, while the active substances in guarana boost energy, maintain endurance and improve mental sharpness. To see what happens when these performances are combined, Microphyt asked the Department of Kinesiology and Sport Management (KNSM) at the prestigious Texas A&M University (TAMU) to carry out a clinical trial in accordance with best practices (randomized, double-blind and placebo-controlled). More than 60 experienced gamers tested GamePhyt™ for 30 days. The first results are particularly impressive in terms of cognitive performance: GamePhyt™ significantly improves focus and memory, reaction time and decision-making, and reduces mental fatigue. The effects were clear after a single dose and just 15 minutes! GamePhyt™ also enhanced sleep quality and visual comfort – and all these benefits come without side effects.
Results unveiled at SupplySide West 2022
GamePhyt™ is the first completely natural ingredient developed for gamers – and it also offers great potential advantages for anyone engaging in sustained mental and/or physical activity such as students, young people with demanding jobs and athletes.
Manufacturers of food supplements and sports nutrition brands take note: GamePhyt™ will initially be marketed in the United States. The Microphyt teams will be in the U.S. at the SupplySide West show to exclusively unveil the full details of the clinical trial. To see the presentation of the GamePhyt™ clinical trial results, come along to the Supplier Presentation Theater, booth 3077, on November 3 at 11am. Discussions will continue at the Microphyt booth (number 5074), where GamePhyt™ samples will be available, together with samples of Microphyt’s other ingredient for the prevention of cognitive decline, BrainPhyt™. Europe will have to wait a few more months before it can benefit from these great ingredients, which will be available in powder form, ready to incorporate into capsules, gummies or snacking products.
A microalgae extract produced in France and based on an exclusive technology
Microphyt, a pioneer in microalgae-based natural solutions for nutrition and well-being, has designed and developed a patented state-of-the-art technology: CAMARGUE photobioreactors. Using this innovative technique, Microphyt can grow Phaeodactylum tricornutum microalgae in a closed environment, in a controlled, sustainable and environmentally-friendly way. The subsequent extraction process isolates the useful molecules (both individual molecules and molecules acting in synergy) for their health benefits. This is how the microalgae extract used in GamePhyt™ is produced, before being combined with guarana.
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Discover GamePhyt™, the first 100% natural bioactive complexe from Microphyt, specifically designed for gamers
The results of the clinical trial for Microphyt’s new ingredient GamePhyt™ are out: they are outstanding and extremely promising! Microphyt will unveil the full study at the international SupplySide West show in November 2022 in Las Vegas.
Devoted e-gamers and all those looking to improve their powers of concentration have something to get excited about! The results of the clinical trials for the new ingredient GamePhyt™ are out, and they are outstanding and extremely promising. Microphyt will unveil the full study at the international SupplySide West show in November 2022 in Las Vegas. In the meantime, here’s a sneak preview of the first findings.
With the development of GamePhyt™, a new ingredient that meets very specific consumer needs, Microphyt is continuing its rise to global leadership in the production of natural active ingredients derived from microalgae.
GamePhyt™ is a unique patented combination, the culmination of three years of research.
Improved reaction time and concentration – naturally and with no side effects
GamePhyt™ harnesses the synergies between the outstanding qualities of fucoxanthin-rich microalgae and the benefits of guarana, which contains guaranine. The extract of Phaeodactylum tricornutum microalgae acts to improve cognitive functions such as memory and ease of learning and also reduces stress, while the active substances in guarana boost energy, maintain endurance and improve mental sharpness. To see what happens when these performances are combined, Microphyt asked the Department of Kinesiology and Sport Management (KNSM) at the prestigious Texas A&M University (TAMU) to carry out a clinical trial in accordance with best practices (randomized, double-blind and placebo-controlled). More than 60 experienced e-gamers tested GamePhyt™ for 30 days. The first results are particularly impressive in terms of cognitive performance: GamePhyt™ significantly improves focus and memory, reaction time and decision-making, and reduces mental fatigue. The effects were clear after a single dose and just 15 minutes! GamePhyt™ also enhanced sleep quality and visual comfort – and all these benefits come without side effects.
Results unveiled at SupplySide West 2022
GamePhyt™ is the first completely natural ingredient developed for e-gamers – and it also offers great potential advantages for anyone engaging in sustained mental and/or physical activity such as students, young people with demanding jobs and athletes.
Manufacturers of food supplements and sports nutrition brands take note: GamePhyt™ will initially be marketed in the United States. The Microphyt teams will be in the U.S. at the SupplySide West show to exclusively unveil the full details of the clinical trial. To see the presentation of the GamePhyt™ clinical trial results, come along to the Supplier Presentation Theater, stand 3077, on November 3 at 11am. Discussions will continue at the Microphyt booth (number 5074), where GamePhyt™ samples will be available, together with samples of Microphyt’s other ingredient for the prevention of cognitive decline, BrainPhyt™. Europe will have to wait a few more months before it can benefit from these great ingredients, which will be available in powder form, ready to incorporate into capsules, gummies or snacking products.
A microalgae extract produced in France and based on an exclusive technology
Microphyt, a pioneer in microalgae-based natural solutions for nutrition and well-being, has designed and developed a patented state-of-the-art technology: CAMARGUE photobioreactors. Using this innovative technique, Microphyt can grow Phaeodactylum tricornutum microalgae in a closed environment, in a controlled, sustainable and environmentally-friendly way. The subsequent extraction process isolates the useful molecules (both individual molecules and molecules acting in synergy) for their health benefits. This is how the microalgae extract used in GamePhyt™ is produced, before being combined with guarana.
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Microphyt, beneficiary of the 2021 ‘France Relance’ stimulus plan, obtains its first clinical results validating the effectiveness of a new nutritional ingredient derived from microalgae .
- The effectiveness of the ingredient GamePhyt™ on cognitive function has been proven as part of a clinical trial coordinated by Microphyt.
- These are the first results of an international program of preclinical and clinical trials coordinated by Microphyt, focusing on numerous segments of human nutrition.
- The €3 million grant obtained from the ‘France Relance’ plan enabled Microphyt to implement these trials and encourages the development of natural ingredients derived from microalgae.
Baillargues (Hérault-France), September 22, 2022.
Microphyt, winner of the ‘France Relance’ call for proposals designed to support national strategic sectors, has received a €3 million grant to boost the development, production and marketing of innovative natural active ingredients derived from the untapped potential of microalgae.
Microphyt’s ambition is to develop new unique ingredients derived from microalgae for the nutrition and cosmetics sectors. The preclinical and clinical development program implemented by Microphyt is strategic in that it validates the effectiveness of these natural ingredients in the fields of human nutrition. An international program of preclinical and clinical trials coordinated by Microphyt is currently focusing on numerous applications in the field of human nutrition, such as cognitive function, weight management, recovery and sports performance. The ‘France Relance’ plan has helped to implement these trials by allocating a €3 million grant to Microphyt.
According to Christel Lemaire, Head of Marketing Novel Nutrition at Microphyt: “The ‘France Relance’ plan has given us a real boost for marketing Microphyt’s innovations. It will give us access to extensive clinical trial programs with internationally recognized and meticulous scientific partners. This major advantage will help us to check the effectiveness of our ingredients on various health benefits so that we can subsequently market our ingredients worldwide.”
Microphyt has obtained the first results of a clinical trial to assess the effectiveness of GamePhytTM on various parameters linked to the end-consumers’ needs (e-gamers for the e-sports market). GamePhytTM is proven to have very positive benefits on cognitive functions, such as improved decision-making and reaction times as well as greater concentration and reduced mental fatigue.This double-blind, randomized and placebo-controlled trial was implemented in close cooperation with Professeur Richard Kreider’s team at Texas A&M University in the United States. Based on a rigorous methodology, the trial provides high-level evidence of effectiveness from a scientific perspective.
According to Jonathan Maury, Head of Clinical Research Novel Nutrition at Microphyt: “As well as yielding extremely positive results, this initial trial also reflects Microphyt’s ambitious approach, which considers science as a founding value in the commercial development of innovative ingredients. We want to work with the best international research teams in their respective fields, as is the case with Professor Kreider’s team, for example. By the end of the year, detailed results will be communicated during international congresses and in a scientific article supporting the launch of GamePhytTM, which is scheduled to take place at the SupplySide West trade show in Las Vegas (US) in November 2022”.
Click on the picture to know more about this Ingredient About Microphyt- https://www.microphyt.eu
Microphyt specializes in developing, producing and marketing natural ingredients derived from microalgae. For over 10 years, Microphyt has been tapping into microalgae to find unique solutions for nutrition and well-being. Microphyt’s patented technologies, which are developed in-house, enable the controlled industrial-scale and sustainable production of a great diversity of microalgae. The company’s ambition is firmly focused on producing unique molecules with high added value. Based in Baillargues, near Montpellier (34), Microphyt currently employs 47 people and has filed 7 patent families.
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Microphyt, the microalgae expert, celebrates 15 years old : from innovative French start-up to global leader
The wonderful world of microalgae is yielding its secrets and creating opportunities for natural ingredients in the nutrition and cosmetics industries. As its competitors grapple with technological limitations, Microphyt, an innovative French marine biotechnology company, does things differently. It uses patented, controlled, environmentally friendly processes to produce microalgae on an industrial scale with the aim of extracting active natural ingredients with high added value. The innovative young firm based near Montpellier in the south of France is well on its way to global dominance. It’s a success story that we can expect to hear a lot more about.
Mediterranean Sea “All geography begins with the sea,” as French historian Jules Michelet liked to say.[1] And we might add that if it weren’t for the sea, life would not have emerged at all.
Microalgae are unicellular photosynthetic organisms that were instrumental in the origins of our time here on earth. Unlike macroalgae – or seaweed –, which can be found washed up on the shore, microalgae are invisible to the naked eye. They have been developing for more than 3 billion years in their natural habitats of seas, oceans, rivers and lakes. They are the main components of phytoplankton and are thought to number somewhere between 100,000 and more than a million species, only a minority of which have been identified to date.
Microalgae – vast yet underexploited potential
One of the strengths of microalgae is their ability to adapt to their environment by synthesizing metabolites, giving them transformative powers within their cells. They convert light energy and carbon dioxide from the air (CO2) into organic biomass and oxygen (O2) via photosynthesis. This alchemy generates an impressive concentration of active principles such as pigments, long-chain essential fatty acids, vitamins and amino acids.
Microalgae are the first link in the food chain and are the only living organisms capable of naturally producing polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are then found in the organisms that ingest them. Another quality related to photosynthesis is the fact that microalgae produce 40% of the oxygen that we breathe, while absorbing CO2 from the air.
It is their remarkable wealth of active principles that makes them unique. The Aztecs were well aware of the potential of microalgae – they were regular consumers of spirulina, one of the most common microalgae used nowadays. But in Europe, it was not until the 1940s that scientists began to make use of their high protein content in food, especially to tackle the problems of famine. The first hatcheries for molluscs and microalgae production for aquaculture feed were built in the late 1970s in France, paving the way for future companies specializing in microalgae.
Asterionella formosa, the microalgae that inspired the company’s logo Extensive research being carried out all over the world is beginning to reveal some of the secrets of microalgae. Technological processes are being used to extract ingredients for use in nutrition and health, pharmaceuticals and cosmetics, and more broadly for green chemistry applications.
Microphyt, a pioneer with a vision
Microphyt, based in Baillargues, near Montpellier in southern France, is one of the French pioneers specializing in microalgae. Two trailblazers were behind this innovative French marine biotech established in 2007: Arnaud Muller-Feuga, a world-renowned microalgae expert and former researcher at Ifremer (France’s National Institute for Ocean Science) and the CEA (the French Alternative Energies and Atomic Energy Commission), who was joined in 2008 by Michel Lemar, a specialist in the industrialization of bioprocesses for health.
Convinced that the natural qualities of microalgae could help overcome challenges related to nutrition and well-being, they laid the scientific foundations for CAMARGUE, a technology patented in 2009 that is fundamental to Microphyt’s success. CAMARGUE reflects one of the company’s steadfast commitments: natural products must be sustainable. So Microphyt decided to handle the entire manufacturing process for its natural active ingredients derived from microalgae and to optimize each stage, satisfying the physiological needs of microalgae and adopting an environmentally responsible approach.
Microphyt’s founders have now retired but they remain closely involved in the future of the company as Scientific Consultant and Process and QHSE Consultant[2].
CAMARGUE, a technology with a difference
CAMARGUE is an exclusive, unique technology based on hydro-biomimetic principles. The aim is to reproduce the natural environment and harness the full biological potential of microalgae, while offering a high level of control. Twenty tubular 5,000-liter photobioreactors, creating a controlled loop of 2,000 meters, have been designed to culture unique microalgae strains for industrial-scale production. The flow system preserves cell integrity, optimizes gas exchange, provides agitation and creates optimal culture conditions.
The technology is used to produce large quantities of sensitive species with high added value. The production platform is linked to an integrated extraction plant, enabling Microphyt to develop and produce unique natural ingredients derived from microalgae.
The unique nature of Microphyt’s production platform is based on:
- Access to the vast diversity of microalgae, paving the way for new applications in the fields of nutrition and cosmetics,
- High active principle content thanks to optimal culture conditions,
- A high level of control, offering full traceability and the quality level demanded by target industries,
- The possibility of industrial scale-up for any microalgae species with laboratory-proven biological interest for the fields of nutrition and cosmetics,
- Modular and versatile systems, enabling simultaneous production of several species,
- Environmentally friendly production involving recycling of culture media and extraction solvents.
CAMARGUE Photobioreactors A sustainable & rational approach
Microphyt’s respect for natural ingredients and commitment to reducing its environmental impact are not empty slogans. The procedures it uses were carefully designed to be as sustainable as possible. The microalgae cultivated in CAMARGUE photobioreactors capture 4.3 times more CO2 on average than traditional systems for the same surface area. Photosynthesis is triggered by an LED lighting system powered by an entirely renewable, local energy supply. Natural solvents are used to extract the bioactive compounds and are recycled after use. The microalgae are grown using a rational, carefully devised method, with no pesticides or GMOs; they are provided with the nutrients they require in optimal quantities to meet their physiological needs. The Microphyt strain library is composed of more than 30 microalgae species and complies with operating conditions and new directives resulting from the Nagoya Protocol – Convention on Biological Diversity. In 2018, the entire company adopted a CSR strategy and received EnVol[3] certification for its action in favor of the environment.
Growth driven by a bold strategy and solid results
The company’s overriding aim is to develop, produce and propose the best natural ingredients based on microalgae. Microphyt’s continued rapid development reflects its considerable investments in innovation and the expertise of its teams. The teams are imbued with a strong R&D culture; they work in close collaboration with French and international specialists recognized for their skills and foster partnerships with scientific institutions at the forefront of biotechnology and microalgae research. Since it was established, Microphyt has explored more than 40 microalgae strains, and it is currently working on around 30 ingredients for the nutrition and cosmetics markets.
Microphyt : unique natural ingredients
Microphyt’s ambition has always remained the same: to provide natural ingredients with high added value derived from microalgae, via an integrated production process that is carefully controlled from start to finish. The qualities of these ingredients can provide specific proven benefits: maintainance of cognitive function in elderly individuals; boost of cognitive performance in a younger population; support for weight control; and skin protection, especially from the effects of aging, sun exposure and urban pollution. Each ingredient, particularly when it comes to the food supplement industry, has undergone more than a thousand analyses performed by a dozen independent, certified laboratories. All the ingredients were approved by the relevant national and European scientific authorities before being brought to market.
The laboratories and brands that incorporate these ingredients in their end products stand apart from their competitors in the nutritional supplement and cosmetics industries. Microphyt’s ingredients respond to the growing demand from consumers for natural, plant-based products that protect their health and well-being safely and effectively while responding to environmental and social challenges. By 2026, Microphyt will have added around ten new natural ingredients for nutrition and around twenty active and functional natural ingredients for cosmetics to its portfolio.
Microphyt’s two first flagship products
BRAINPHYT is a natural bioactive derived from microalgae that helps to maintain cognitive function throughout life by enhancing short-term and long-term memory, improving learning and reducing stress. Recognized by the US Food and Drug Administration (FDA) as a “new dietary ingredient” in 2019, it is marketed in the United States.
RENOUVELLANCE, derived from Porphyridium cruentum, contains a pigment rarely found on the market that offers significant benefits for skin photoaging and anti-aging in general (phycoerythrin), as well as exopolysaccharides with anti-inflammatory, anti-hyaluronidase, moisturising and antioxidant properties.
Natural ingredients, a growth market
Microphyt is targeting niche, high value-added, fast-growing markets in the sectors of nutrition (food supplements), wellness and cosmetics. The development of these sectors is being driven by an increasing demand for natural ingredients.
The global market for ingredients in the nutrition and cosmetics industries currently represents around USD 30 billion, with annual growth of 2 to 4%. The share of natural ingredients (including algae and microalgae) is seeing a strong upward trend of around 8% per year because of the consumer appeal of these products. They represent a global market of approximately USD 4 to 5 billion.
Developing the largest microalgae production platform in the world
Not a year goes by without a major event to boost Microphyt’s development. In 2021, Microphyt was selected in the “Flagship” call for proposals launched by the Bio-based Industries Joint Undertaking (BBI JU), a European initiative to promote bioindustries at global level. The aim of “Flagship” programs is to establish leading industrial sites at European level through the development of promising technologies. The SCALE program led by Microphyt is the only one of the programs selected that makes use of aquatic resources, which illustrates the unique nature of its existing production platform.
In August 2021, supported by the European Union and a consortium of 11 prestigious partners, Microphyt embarked on the extension of its SCALE production platform, based on the concept of a microalgae biorefinery. The aim is to naturally exploit all the fractions of microalgae by developing several ingredients from the same biomass yet limiting the number of co-products as much as possible. For example, biomass from Phaeodactylum tricornutum algae serves as the basis for the production of the ingredient BrainPhyt. The fractions that are not used by this ingredient are now used as an ingredient for the cosmetics industry.
With the extension of the SCALE program, a 520m3 biomass production capacity will be installed on Microphyt’s site in Baillargues, near Montpellier. Microalgal biomass will be produced via CAMARGUE tubular photobioreactors and directly extracted on site using sustainable extraction processes. This ability to develop natural ingredients derived from microalgae and produce them on a large scale will make the SCALE platform a global leader. It will be unique in terms of the range of ingredients that it is capable of generating and its reliable, industrial-scale supply capacity. These natural ingredients will replace petrochemical ingredients in cosmetics and also plant extracts produced in poorly controlled, unsustainable conditions for the nutrition industry.
The world’s first microalgae biorefinery under construction on Microphyt’s site in Baillargues (South of France) The four-year SCALE program received a grant of €15 million from BBI JU and the European Commission in 2021. The program will create nearly 60 direct jobs and 190 indirect jobs and is set to be replicated elsewhere in Europe. In line with the Microphyt roadmap, SCALE consolidates Microphyt’s three growth areas: (i) direct marketing of new natural ingredients to nutritional supplement laboratories and cosmetic brands, (ii) a large-scale production platform for the reliable, sustainable supply of ingredients, and (iii) an unparalleled capacity for innovation that lays the foundations for the development of unique ingredients for the fields of nutrition and cosmetics.
Microphyt, the leader of a new international industry
Over the coming decade, stakeholders in the nutrition and cosmetics sectors will be forced to implement new natural, sustainable solutions in response to social and global challenges. Microalgae are the perfect solution to meet these needs: they are a natural product that is produced sustainably and can be cultured in controlled conditions, and they have an incredibly diverse range of active principles. Microphyt is ideally placed at the forefront of this momentum and is committed to playing its part in the development of a global industry for natural ingredients derived from microalgae.
[1] La Mer, 1861
[2] Quality, Health, Safety and Environment
[3] EnVol, a French initiative to encourage voluntary commitment by companies to the environment. https://www.envol-entreprise.fr
Vincent USACHE Microphyt Chief Executive Officer
Julie PERSON Microphyt Project Coordinator & Communication.
Article published in La Revue Maritime no. 522 – March 2022 – Special report on Occitania – Microphyt, the microalgae expert – p.30-36
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Join us this fall ! 🍂
During the fall 2022, Microphyt will be present at several industry events. We hope to take this opportunity to meet you and share with you about our unique ingredients extracted from microalgae. Come and join us to these various events:
September 16th: Cosmetic Webinar – Back to school starts strong for cosmetic team which organize its 2nd webinar. This online event is dedicated to present microalgae and neurocosmetics, the new allies of sensitive skin. For this occasion, Karl Lintner, cosmetic consultant with a neurocosmetic expertise and Elodie Gras Lavigne form Neuron Experts, our CRO which realized our in-vitro studies for Luteana™. Neuron Expert is specialized in study of neuro-active compound.
We have chosen to organize 2 meetings: one in French at 2p.m. and one in English at 5p.m. (CEST)
Location: on line, with our webinar platform
September 20th: Microalgae Webinar – Nutraceutical teams takes over by hosting and sponsoring the webinar “Fucoxanthin and Phaeodacylum tricornutum” organized by EABA (European Algae Biomass Association). The occasion for Microphyt to tell its story through the microalgae Phaeodactylum tricornutum.
Time: 2p.m. (CEST)
Location: on line
October 5-7th: Sport & Active Nutrition Summit – Christel Lemaire will be present to stay informed of sports nutrition and also to speak with you of microalgae benefits for sportsmen.
Location: Netherland, Amsterdam, Marriott Hotel
Book a meeting: contact@microphyt.eu
October 15-19th: SIAL – In order to democratize the use of microalgae in the food, Microphyt will be exhibitor at the International Food Trade Show on Business France booth, start-up space. It is for us the occasion to expose our research works in partnership with Paul Bocuse institute research and innovation center as part of the SCALE project.
Location: France, Villepinte, Parc des Expositions de Paris-Nord Villepinte
Book a meeting: contact@microphyt.eu
October 31th – November 3rd : Supply Side West – Microphyt nutraceutical team will be exhibitor at international tradeshow dedicated to nutrition and food supplement. Book in advance your meeting with our team and visit our booth 5074. Vincent Usache, CEO, Ilya Zhivkovich, Chief business officer, Christel Lemaire, Marketing nutraceutical manager and Jonathan Maury Clinical studies manager will be there to exchange and introduce you our new ingredient. Come to theatre supplier booth 3077 on November 3rd, for listen Christel with her presentation « Power-up esports performances with GamePhyt™, a novel natural bioactives complex by Microphyt ».
Location: United-States, Las Vegas, Mandaly Bay Convention Center
Book a meeting: contact@microphyt.eu
November, 1st – 3rd : In Cosmetics Asia – Microphyt cosmetic team will be exhibitor at the international cosmetic ingredient tradeshow and will present its brand new bioactive ingredient for cosmetic industry. Nora Vandamme, business developer USA and Cyrielle Houdin, marketing cosmetic ingredient manager, will be present and delighted to exchange with you and your cosmetic project.
Location: Thailand, Bangkok, Bangkok International Trade & Exhibition Centre
Book a meeting: contact@microphyt.eu
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
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Tisochrysis lutea, a golden Tahitian microalgae with beneficial properties
The origin and adaptability of Tisochrysis lutea, together with its composition rich in compounds of interest, make it a highly promising microalgae with extraordinary capabilities that will be a useful addition to cosmetic products for sensitive skin. Inspired by the potential of Tisochrysis lutea, Microphyt rose to the challenge of using it to create a unique oily active ingredient as part of an innovative comprehensive solution.
Tahiti, an idyllic but hostile environment
Tisochrysis lutea was first identified in the 1980s in French Polynesia. This idyllic place for humans is a hostile habitat for microorganisms like microalgae. Polynesia is composed of volcanic islands which sit on tectonic plates, leading to the release of high levels of acidity and phosphorus. The water around the islands is also high in salts and very warm, with an average temperature of around 29°C.
Singular characteristics
Tisochrysis lutea is a golden microalgae that belongs to the Isochrysidaceae family. In morphological terms, it is a haptophyte algae, in other words a single-cell algae with a plastid that is golden-brown in colour owing to the carotenoids that compose it. T. lutea has a very thin wall composed exclusively of sugars. It is circular in shape with a diameter of approximately 6µm. What makes T. lutea stand out is its remarkable adaptability. Despite its thin wall and sensitivity, its powerful metabolism has enabled it to adapt over the centuries to survive in the hostile environment of the Polynesian lagoon.
A unique composition with real potential for the cosmetic industry
Tisochrysis lutea contains a wide variety of natural molecules of interest: lipids, proteins, carbohydrates and pigments.
The main pigments are chlorophyll and carotenoids. T. lutea particularly contains a large quantity of fucoxanthin, which belongs to the carotenoid class, and more specifically the xanthophyll subclass. Xanthophylls, found in the chloroplasts of plant cells, offer protection against the harmful effects of excessive light and are involved in the photoprotection of the lipid membrane.
Fucoxanthin, which can only be found in the marine world, is a yellow pigment whose amphiphilic structure enables it to be integrated more effectively into the skin’s structure. When it comes to sensitive skin, fucoxanthin regulates the inflammation of the cells that structure the skin’s surface (keratinocytes), immune cells in the skin and also sensory neurons. More generally, fucoxanthin naturally restores the balance of all these skin cells (via homeostasis) in the event of an overactive inflammatory response in the skin. This action on multiple cells tackles the problem of sensitive skin by addressing the phenomenon in all its complexity.
Scientific research on this microalgae particularly focuses on long-chain fatty acids. T. lutea contains a large quantity of essential polyunsaturated fatty acids, like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which belong to the precious omega-3 family. From a cosmetic viewpoint, these compounds are of interest because they offer the skin a source of lipids that are vital in strengthening the extracellular matrix – the supporting network that boosts the skin’s firmness.
T. lutea also produces phytosterols that complement the action of omega-3s. These plant sterols have similarities with the cholesterol in the skin, which helps maintain cell integrity. Research has shown that the sterols offer an anti-ageing effect by activating the production of collagen 1 and 2 and reducing the expression of pro-inflammatory mediators (interleukin-6) and the enzymes involved in the degradation of the extracellular matrix (MMP1).
Microphyt was keen to explore the potential of this unique microalgae and was able to extract a precious oil with standardised fucoxanthin content and also containing powerful compounds such as omega-3s and sterols.
With its unique, rare and powerful composition, Luteana™ is a comprehensive solution to rebalance and soothe sensitive skin.
To find out more about our new active ingredient, click here.
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Microphyt experts: Mélanie Lefèvre, cosmetic formulation specialist
Microphyt can count on the expertise of cosmetic formulation specialist Mélanie. We take a closer look at her invaluable skills and why they are so appreciated by clients.
Mélanie Lefèvre, always striving to identify the best cosmetic formulations based on natural active ingredients derived from microalgae. Mélanie has cosmetic formulation in her blood. A qualified chemist with a Master’s in cosmetic formulation and development from the prestigious ISIPCA school,[1] she pursued a career at L’Oréal, L’Occitane and Pierre Fabre before joining Microphyt, keen to harness the potential of microalgae.
Could you describe your work in cosmetic formulation?
I would say that I am looking for the ideal context that will best bring out the remarkable properties of the cosmetic ingredient derived from microalgae. To do this, I create a map of the ingredient, including its texture, color and olfactory signature, and also where it was sourced and what it does. Then I imagine and create a variety of different formulations. During this investigative process, I also test various raw materials, formulations and packaging that will work best with the product. The aim is to propose a suite of formulas that maximize the potential of the microalgae extract that we are marketing.
In practice, what are the stages in the process?
I start with the ingredient, a microalgae extract identified and developed by the Research & Development team for its cosmetic benefits. I test it in the lab to see how it reacts when it comes into contact with other natural substances in various types of formula. After 3 to 4 months of analysis and 6 months in total to confirm the stability of the formulas developed, I draw up a formulation guide for the client. It contains a description of all the characteristics of the extract, formulation guidance especially in terms of pH, temperature and compatibility with other ingredients, and all the formulas that I have developed.
How are ingredients derived from microalgae different from the other active ingredients that you have studied?
Microalgae are natural micro-factories that are novel and powerful. They are remarkable both for their intrinsic qualities, many of which are not well known – their antioxidant, regenerative, moisturizing properties –, and for their wonderful palette of colors.
Why does Microphyt, a specialist in microalgae-based ingredients, offer expertise in formulation?
With in-house experts, Microphyt has full knowledge of the reaction of active ingredients within a formula. And that’s really helpful for our clients – we provide them with a bespoke product by offering several natural formulas that contain our ingredient. The formulation guide helps speed up and optimize the development phase, and we know how important that is in a hypercompetitive market.
You previously worked in major corporations. Why did you join Microphyt?
I had always previously worked for companies that offer end products. Being involved in the ingredient side means focusing on the upstream stages and playing an active role right from project kickoff. I was also attracted by the size of Microphyt and the dynamic nature of the company. I find it really exciting to be contributing to its growth. There is a great atmosphere and everything points towards the company becoming a real global leader in its field.
What are the main qualities you need to be a formulation specialist for Microphyt?
- Creativity, which is vital to develop new applications.
- Rigor to analyze the reaction of the active ingredient and identify its product environment.
- Good communication skills to work together with the R&D, marketing, regulation and quality departments.
And finally, what is the favorite microalga of Mélanie Lefèvre, Microphyt formulation specialist?
The microalga Porphyridium cruentum for its natural pink color and its protective properties that combat the combined effects of pollution and UV rays on the skin.
[1] A French higher education institution in the field of perfume, cosmetics and food flavoring.
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Sensitive skin: neuro-immuno-cutaneous system paves the way for new solutions
Sensitive skin can cause dryness, redness, tightness and other unpleasant symptoms that have a negative impact on our well-being. But new solutions now exist for this problem that affects half the population. Research and the emergence of neurocosmetics have demonstrated how the neuro-immuno-cutaneous (NIC) system can disrupt the skin’s balance. We take a closer look.
NIC – these three little letters point to the existence of multiple interactions between skin cells (keratinocytes, melanocytes and fibroblasts), nerve fibres and immune cells. Scientists only discovered the neuro-immuno-cutaneous system very recently[1]. The NIC system perceives various stimuli and transmits them to the central nervous system. These exchanges take place via cell-cell contacts and biological mediators (chemical signals that carry information between cells). The barrier and sensory functions of the skin are under the influence of this system, meaning that if the NIC network is disrupted, the skin becomes sensitive and expresses this through various chemical signals that have a direct impact on skin well-being, resulting in symptoms such as itching, redness, tightness and dryness.
Understanding the NIC network to restore the balance of sensitive skin
If the NIC network encounters physical, chemical or emotional stimuli, it can create an imbalance, resulting in overproduction of neuromediators. The network is unbalanced at all levels, causing it to overreact and get caught in a self-reinforcing vicious circle, leading to over-sensitive skin. So if we are to improve the health of sensitive skin, we need to maintain a balanced NIC network.
If the NIC network encounters physical, chemical or emotional stimuli, it can create an imbalance, resulting in overproduction of neuromediators. The network is unbalanced at all levels, causing it to overreact and get caught in a self-reinforcing vicious circle, leading to over-sensitive skin. So if we are to improve the health of sensitive skin, we need to maintain a balanced NIC network.
Luteana, the new comprehensive solution
Microphyt, which specialises in harnessing the power of microalgae, has developed Luteana, a comprehensive solution capable of restoring the balance of the NIC system. This oily extract derived from a golden Tahitian microalgae is a concentrated blend of powerful active ingredients, especially fucoxanthin, which regulates the NIC system and soothes the skin. The demonstrated neuroprotective and anti-inflammatory benefits[2] of fucoxanthin, a pigment that can only be found in the marine world, have a lasting natural effect on atopic skin.
To find out more about our new active ingredient, click here.
Neurocosmetics: the link between beauty and well-being
Since the 1990s, neurocosmetics has given rise to extensive research both at universities and by brands that manufacture active ingredients or cosmetic end products. In 2000, Laurent Misery, a dermatology professor and director of the neuroscience laboratory at the University of Western Brittany, defined neurocosmetics as the understanding of skin innervation and the observation of products applied to the skin that have an impact on the cutaneous nervous system or a general effect on skin mediators. This field demonstrates the crucial links between beauty and well-being, currently the focus of much interest among industry stakeholders.
[1] Debroas et al., Interactions neuro-immunes dans la peau : Un lien entre douleur et immunité, Med Sci (Paris),2018 , Vol. 34, N° 5 ; p. 432-438
Vidal et al., The importance of the neuro‐immuno‐cutaneous system on human skin equivalent design. Cell Prolif. 2019; 52:e12677
[2] Zaho et al., Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells. Neurochem Res 42, 667–677 (2017); 2. Natsume et al., Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells. Int. J. Mol. Sci. 2020, 21, 2180; 3. Tavares et al., 2020
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A specialist insight : Jean-Paul Cadoret “I bet on the microalgae development”
How can microalgae respond to environment and societal developments? What strength can Europe rely on to become the leader in this field? To find out all there is to know about the powers of microalgae, we met with one of the greatest experts on the topic, Jean-Paul Cadoret, President of the European Algae Biomass Association (EABA) of which Microphyt is a member.
What role do microalgae play in addressing the environmental and societal issues of global warming and food sovereignty?
A major advantage of microalgae is in its incredible biodiversity (>200,000 species). They offer a broad range of applications thanks to their unique characteristics and properties. Microalgae could be a natural source of vitamins, antioxidants, lipids, sugars, proteins, etc. their metabolism allows us to search for exactly what interests us, depending on the species.
We must, however, put this valuable resource into a European regulatory context, where the list of approved foodstuffs is restricted. Furthermore, the cost of microalgae production is higher than that of agricultural production. This is one of the reasons which prompted French and European microalgae professionals to focus on the added value of these microorganisms.
In environmental terms, their cultivation is sustainable. It doesn’t compete with agricultural land, nor depletes the sea or ocean from microalgae to cultivate them! All of the development stages of microalgae in photobioreactors, such as those at Microphyt, are monitored. As plants, they also enable the virtuous recycling of carbon. Certain wastewater treatment plants use microalgae downstream because they remove nitrogen and phosphorous from wastewater.
At present, the greatest application sectors are aquaculture, cosmetics, nutritional supplements and functional food.
Do microalgae have unique properties that aren’t found in other plants?
They are incredibly effective because, unlike terrestrial plants, they don’t lose any energy when they absorb water through their roots and irrigate their leaves. They have everything to hand as they are immersed in their nutritional environment. The following comparison speaks for itself: you obtain 1 gram of biomass per day for 1 m2 of plants cultivated in a temperate environment. In the same proportions, you harvest between 10 and 20 grams of biomass with microalgae. The yields are exceptional!
Another difference compared to terrestrial plants is that marine microalgae provide polyunsaturated fatty acids such as omega-3 and omega-6 as well as amino acid balances which are highly sought after in food. When used in cosmetics, microalgae can produce molecules which offer a high level of UV protection. Their antioxidant properties are also beneficial, for example for skin products.
What’s more, certain microalgae have unique pigments – molecules that cannot be found on land or in any terrestrial plants.
How do European microalgae producers compare with producers in other continents?
In a nutshell, Europe is very strong in microalgae fields, whereas Asia plays a prominent role when it comes to macroalgae.
In the United States, to place food on the market a declaration must be submitted to the Food and Drug Administration (FDA), which opens up a huge market to US producers.
European microalgae producers are smaller but there are many of them. As a whole, they focus on the high value-added products with an extensive research into the science and functionality behind these ingredients. The European Union has encouraged this trend by promoting collaboration with universities.
Today, our European administration contacts understand the power of microalgae, the jobs that they can create and their role in European independence, and discussions are very constructive. EABA outreach efforts have certainly helped with this!
Which obstacles need to be overcome to develop these natural solutions on a large scale?
One of the main obstacles is the complexity of the European machine. Laws need to be simplified. There is a great paradox between the Europe which supports microalgae projects and the Europe which promulgates laws that severely restrict their development. Europe wants to protect itself and its consumers, while encouraging research and industrialization.
Another major obstacle is consumer acceptance. Consumers need to realize that the incredible qualities of microalgae meet their expectations in terms of well-being, healthier diet, respect for the environment and sustainability. Microalgae are very often confused with pollutant species of algae. It’s our job to better promote the exceptional powers of microalgae.
From the technology perspective, I see no more obstacle. The European technological ecosystem adapts and responds very fast. It is creative, even pioneering. Not a month goes by without a new innovation regarding photobioreactor processes.
Looking ahead, I bet on the consumer demand-driven development of microalgae and the promotion of downstream processes, i.e. this incredible biomass which opens up numerous news areas of application.
Brief biography of Jean-Paul Cadoret
- Jean-Paul Cadoret is President of the European Algae Biomass Association, a key contact within the European Union.
- He is also scientific director of Algama, a supplier of microalgae-based food ingredients.
- This specialist has published over 70 articles on algae and filed 8 patents.
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Harnessing biotechnology for sensitive skin
Sensitive skin is a complex condition with multiple causes and symptoms. It is thought to affect half of the world’s population and is a problem that needs to be taken seriously. But help is at hand – new solutions are available.
External and internal causes
The factors behind sensitive skin fall into two categories. First, there are exogenous triggers such as climatic conditions: cold, wind, dry air, exposure to UV rays and pollution as well as excessive use of soap, hand sanitiser and cleaning products can all increase the skin’s sensitivity.
Then there are variations in hormone levels caused by stress, menstrual cycles, psychological factors, etc., which can disrupt the skin’s balance.
Varied reactions
Sensitive skin is characterised by hyperreactivity – sometimes chronic – to a simple, minor or even non-existent stimulus.
It often leads to inflammatory reactions (erythema, sensations of heat or burning, etc.). A surge in plasma releases cells that induce an immune response and result in a vasodilation (widening) of small blood vessels known as capillaries. Mediators involved in this reaction include pro-inflammatory cytokines (IL-1β and TNF, for example), small proteins that need to be inhibited to calm inflammation.
Those with sensitive skin can also experience a prickly feeling, tightness or itching. This is generally caused by dry skin. Skin dehydration is indicated by abnormally high levels of transepidermal water loss (TEWL). In healthy skin, TEWL is generally 5g/m²/hour, but in sensitive or atopic skin it can reach 18g/m²/hour. This high level of dehydration can be attributed to a more porous skin barrier and also a reduced extracellular matrix. Restoring the skin involves restructuring the skin barrier and the extracellular matrix by adding more fibre (collagen and elastin).
Innovative solutions
Solutions to treat sensitive skin have developed to take into account the multiple causes behind the condition.
Treatments were initially based simply on hydration, repairing the skin barrier or anti-inflammatory action, but new solutions are now arriving on the market.
Recent studies have demonstrated the crucial interactions between cutaneous, immune and nerve cells in the skin. They form a network known as the neuro-immuno-cutaneous (NIC) system, which plays a central role in the imbalance in sensitive skin. This new finding did not go unnoticed by Microphyt, which responded by developing Luteana™, a cosmetic active ingredient based on microalgae. It rebalances the NIC system, restoring optimal conditions and providing lasting relief for sensitive skin by targeting the root cause of the imbalance. Luteana™ paves the way for a whole new generation of comprehensive solutions that are more effective than traditional temporary fixes.
Click here to find out more about Luteana™.
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Nutrition & well-being: the power of microalgae
Microalgae are an ideal alternative when it comes to meeting food challenges and consumers’ high expectations in terms of a healthy and sustainable diet. Here’s an overview of these super ingredients with proven virtues.
Imagine a library with at least 30,000 works, each containing exceptional information to explore. That’s what the incredible biodiversity of microalgae has to offer. In fact, these microscopic marine plants are behind the very origin of life on earth. Their strength lies in their ability to produce and naturally concentrate an impressive quantity of active compounds, such as proteins (twice the amount contained in soya beans), carbohydrates (up to 20%), lipids, vitamins, trace elements (copper, iron, zinc), mineral salts, carotenoids and other antioxidants. Thanks to a world pioneering cultivation process, Microphyt extracts the best properties from these organisms, in sustainable conditions, for applications in the cosmetics, health and nutrition sectors.
MICROALGAE FOR A HEALTHIER AND SUSTAINABLE DIET
In pursuit of quality and transparency, more and more consumers are seeking to adopt a healthier diet, with due regard for environmental challenges. In France, this goal has resulted in a steady decrease in meat consumption (-12% over the past 10 years1) and a rise in flexitarianism, vegetarianism and even veganism. Microalgae are major allies which meet these requirements. Once incorporated into foods and food supplements, they promote well-being and health. All of this can be achieved without altering natural resources thanks to the unique and patented Microphyt’s hydrobiomimetic technology. In a closed environment that is monitored at each cultivation stage, photobioreactors recreate the natural hydrodynamics which enable microalgae to grow, all in a healthy environment, without GMOs, antibiotics or pesticides.
MICROALGAE: FATTY ACIDS AND PROTEINS GALORE
Microalgae are a natural source of DHA, a polyunsaturated fatty acid belonging to the omega-3 family, which is known to help the body function properly. For example, it slows down cognitive decline due to ageing and has a protective effect on the retina and on neurodegenerative diseases, etc. Microalgae also contain a large quantity of omega-6 essential fatty acids that are found in seeds, cereals, vegetable oils and some meats, and that our body cannot synthesize. Proteins are additional molecules of interest offered by microalgae. They are particularly appreciated by vegetarians and athletes in search of powerful plant proteins.
SPIRULINA AND CHLORELLA, THE HEADLINERS
Spirulina is one of the best-known species of microalgae, also referred to as a ‘food of the future’ by the UN2 since it helps to prevent malnutrition in developing countries. 90% of the 400 tons consumed in France each year is imported3, hence the need to carefully check the origin and quality of this cyanobacterium. Microphyt offers an organic version which is grown in Europe, thereby preserving its super-nutrients: proteins, including 20 amino acids, beta-carotene (a precursor of vitamin A), iron, gamma-linolenic acid (leader of the omega-6s)3 and phycocyanin, an antioxidant pigment. Measured against its sister algae, the freshwater microalgae chlorella stands up equally well. Not only is it rich in proteins, vitamin B12, calcium, magnesium and iron, but it also boosts the immune system and provides omega-3 essential polyunsaturated fatty acids. Spirulina and chlorella are frequently used in everyday food products (yogurt, pasta, tortillas, veggie burgers, etc.) enabling consumers to enjoy both their nutritional quality and their special characteristics (texturizing agent, pigment, etc.).
OTHER SUPER-POWERFUL MICROALGAE FOR THE FOOD INDUSTRY
Although spirulina and chlorella are the most commonly used microalgae in the food and nutraceutical sectors, it would be a shame to overlook other species which have proven qualities and a high added value.
Haematococcus pluvialis, a green freshwater microalga which grows naturally in temperate regions, is an extraordinary source of astaxanthin, the most powerful natural antioxidant to date. It is used primarily in natural food supplements which have an impact on vision and eye health, the brain’s cognitive functions, and the cardiovascular and immune system4.
The microalgae Phaeodactylum tricornutum contains several bioactive molecules, including fucoxanthin, which helps to maintain cognitive functions. In a closed environment, in a controlled, sustainable and environmentally-friendly way, Microphyt technology can extract a ‘super cocktail’ of natural active ingredients from Phaeodactylum tricornutum, whose effects on age-related cognitive decline (short-term memory loss, visuospatial memory loss) have been tested via seven preclinical studies.
Consumers and players in the food and nutraceutics sectors can therefore draw some wonderful active ingredients from the huge culture collection of microalgae, which not only have health benefits, but also play a positive role in preserving the environment. As such, Microphyt is applying its expertise to hundreds of microalgae with powers that are yet to be exploited.
Sources :
1Etude Crédoc CONSOMMATION & MODES DE VIE N°CMV300
2Déclaration ONU – 1974
3Fédération des spiruliniers de France
4Sawaki et al., 2002; Nakamura et al., 2004 ; Saito et al., 2012; Yasunori et al., 2005
Second Edition of Handbook of microalgal culture applied phycology and biotechnology, edited by Amons Richmond and Qiang Hu
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Join us this spring! ☀️🌸
During the spring 2022, Microphyt will present at several industry events. We hope to take this opportunity to meet you and share with you about our unique ingredients extracted from microalgae. Come and join us to these various events:
March 15-17th: BIOKET: Bioeconomy Key Enabling Technologies platform – Vincent Usache, Microphyt CEO will be there on march 15th to participate on two sessions:
– The plenary session dedicated to KETs to unlock the potential of algae for a thriving European blue bioeconomy and will present Microphyt SCALE project – First of its kind industrial platform toward sustainable microalgae-based solutions.
– The session on the Circular Bio-based Europe Joint Undertaking (CBE JU) to fund projects advancing competitive circular bio-based industries in Europe.Location: France, Lille, Grand Palais
April 5-7th: In Cosmetics global – Microphyt will exhibit on in-cosmetics global event, the leading global event for personal care ingredients, and will notably unveil its new innovative bioactive ingredient for the cosmetic industry. Book appointments with our team in advance and visit us at booth P52A.
Book an appointment: contact@microphyt.eu
More information hereLocation : France, Paris, Paris Expo Porte de Versailles
April 27-28th: European Algae Industry Summit – Microphyt will attend this conference which gathers key players within the algae industry (food, feed, nutraceuticals, pharmaceuticals and cosmetics) across the globe. Cyrielle Houdin our Marketing Manager for Cosmetic Ingredients will take part in the session dedicated to “The benefits of Microalgae for Cosmetics.”
More information hereLocation: Iceland, Reykvavik, Grand Hotel Reykjavik Sitgun 38
May 3-4th: NYSCC – This year, we will exhibit at this internationally renowned trade show in New York City. Please send us a message to schedule an appointment or go directly to our stand we share with Premier Specialties, our US distributor. Nora Vandamme, Business Developer USA and Cyrielle Houdin, Marketing Manager for Cosmetic Ingredients will be there to discuss on our newest ingredients.
Location: United-States, New York City, the Jacob K. Javits Convention Center
May 10-12th: Vitafoods Europe – This year we come back to this trade show, The World’s Nutraceutical Event! The perfect place to meet leading suppliers of raw ingredients, dietary supplements such as Microphyt, functional food and stuff. Please come and visit us at our booth. You will be able to chat with Sophie Lagon, Business Development Director and Christel Lemaire, Marketing Manager for Nutraceutical Ingredients.
Location: Switzerland, Geneva, Palexpo
June 7-9th: Nutriform Business Days – This international convention is focused on dietary supplements and nutrition. The occasion to learn about the last trends and meet professionals. Sophie Lagon, Business Development Director and Christel Lemaire, Marketing Manager for Nutraceutical Ingredients, will be present to discuss with you about your nutraceutical projects.
Location : Antibes, France, Palais des Congres
LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, do not hesitate to contact us by email at contact@microphyt.eu or by clicking here.
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SCALE Project website is now launched
Led by Microphyt and launched in June 2021, the BBI-JU Flagship F3 SCALE project has now its own website online. To know all the informations about the project, its partners and ambition, follow the link below. https://www.scaleproject.eu/
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Join us this fall! Take a look at our agenda
By fall 2021, Microphyt will be present at several industry events. The opportunity for you to meet our teams to get to know us better and discover our unique production technology as well as our flagship ingredients extracted from microalgae. Let’s take a glance at the agenda:
– September 9: WEBINAR – Consumer “post-pandemic nutrition trends: role of microalgae-derived bioactives”. This webinar will feature Tim Avila, President of Systems Bioscience Inc. and Rémi Pradelles, Chief Development Officer at Microphyt. We will discuss how the pandemic has changed the expectations of consumers and how and why microalgae can meet these new expectations. We will present you with new underdeveloped species of microalgae and highlight novel active ingredients derived from them. Register here for free!
– September 14-16: NUTRIFORM BUSINESS DAY – We will be physically present in Saint-Raphaël (France) for this 5th international congress of food supplements and innovation. Our nutraceutical division team will be there to meet you and to discuss new innovations from Microphyt.
– September 22-24: PLANT BASED SUMMIT – “From microalgae to nutraceutical ingredient for the prevention of cognitive decline linked to aging”. We will attend this event as a speaker during the Food-Nutraceutical Ingredients session to share our experience on new product developments and to feature our latest innovation BrainPhyt.
– September 23: WEBINAR – “Microalgae, an unexploited natural trasure for skin care”. During this session, we will explore the trends of the blue universe of the cosmetic market and grasp the future of cosmetics through microalgae, discovering the untapped potential of microalgae and the great field of possibilities. In our first webinar on cosmetic trends and microalgae, Pascale Brousse, Founder of Trend Sourcing , and Microphyt’s experts will look at the latest natural innovation in this exciting category! Click here to register for free!
– October 5-7: VITAFOODS EUROPE – French Pavilion – For the return of the trade shows this year, we have chosen to travel to better meet you! We can’t wait to meet you at the Vitafoods Europe trade show in October 2021. Please come and visit us at our booth, located on the French Pavilion! You will be able to chat with the nutraceutical team. Plan a meeting with us: sophie.lagon@microphyt.eu or contact@microphyt.eu
– October 21: WEBINAR – “Amélioration des fonctions cognitives: les microalgues à l’épreuve de la science”. We will speak during a webinar about nutrition and the prevention of cognitive decline organized by the CNSL (Clubster Nutrition Santé Longevité), focusing on microalgae and the improvement of cognitive functions. Click here to register!
– October 27-28: SUPPLY SIDE WEST – Booth #4777 – This year, we will be physically present as an exhibitor for the first time at this internationally renowned trade show in Las Vegas. Please send us a message to make an appointment with us or go directly to our booth #4777 to discuss with our team! Plan a meeting with us: ilya.zhivkovich@microphyt .eu or contact@microphyt.eu
WE ARE LOOKING FORWARD TO SEE YOU AGAIN!
In the meantime, if you have any questions or if you would like more information, feel free to contact us by email at contact@microphyt.eu or by clicking here.
Microphyt’s team
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Microphyt Announces Launch of SCALE, the world’s first fully-integrated microalgae biorefinery.
ABOUT SCALE – KEY TAKEAWAYS
Microphyt, a leading company in the production and marketing of microalgae-based bioactive ingredients is announcing the launch of SCALE to accommodate new products roll out and growing demand:- It will deliver large scale sustainable production of Microphyt’s natural specialty ingredients for nutrition, food & beverage, personal care, and wellness industries.
- Its construction begins at Microphyt’s facility in France in 2021 and represents the first-of-its-kind fully-integrated microalgae biorefinery at an industrial scale.
- SCALE has received a grant of €15m; the single largest award from the Bio-based Industries Joint Undertaking for sustainable aquatic production.
Baillargues (France), July 1st, 2021
The SCALE program, led by Microphyt has been awarded a highly competitive Flagship grant from the « Bio-based Industries Joint Undertaking », a partnership of the European Commission and the Bio-industries Consortium. The 4-year 15 million Euro SCALE project brings together 11 top-tier international partners on a mission to develop the world’s largest microalgae biorefinery. SCALE will address the ever-growing demand for safe and effective nutrition and wellness ingredients produced in a natural and highly sustainable way.A UNIQUE INDUSTRIAL AND MULTI-SPECIES PRODUCTION SITE
Located in Baillargues, near Montpellier in the South of France, the headquarters of Microphyt, will be home to a first-of-its-kind microalgae biorefinery, utilizing the CAMARGUE technology which is capable of extraordinary efficiency in production and extraction of bioactive compounds. CAMARGUE is a unique and proprietary technology, based on hydro-biomimetic principles. Mimicking nature’s most efficient growth conditions, it takes advantage of the full biological potential of microalgae while ensuring a high level of control. A CAMARGUE-based demonstration facility is already in operation at Microphyt and has positioned the company as a global leader capable of producing the broadest diversity of microalgae species at industrial scale. This platform leverages the amazing biodiversity of microalgae, and their unique and beneficial bioactives which offer numerous solutions for nutrition and wellbeing.
Over the course of the 4-year program, the production capacity will increase five-fold, allowing for the development and production of more than 15 new ingredients derived from microalgae for the fields of nutrition and cosmetics. The annual capacity of SCALE will be more than 100 tons of high-value ingredients.AN ECO-FRIENDLY PROJECT FOR A SUSTAINABLE INDUSTRY
Microphyt is dedicated to highly sustainable practices and does not use GMOs or pesticides, has highly efficient water use and actually consumes CO2. SCALE will further accelerate these environmental benefits by integrating renewable energy production enhancing recycling capabilities. SCALE will provide industrial-scale production of environmentally friendly, natural ingredients, that will contribute to reducing petrochemical dependency. In addition, SCALE will aid the attainment of European climate targets of cutting greenhouse gas emissions by 20%.
The natural ingredients sector is growing at 8 to 10% per year and already accounts for a global market between 4 and 5 billion USD. During the replication phase of SCALE, which follows the successful conclusion of the first SCALE facility, projected finished goods revenues of €1 bn Euros are expected to result from SCALE produced ingredients. In addition, the first SCALE facility will create approximately one hundred jobs by 2025.
“For BBI JU, the financing of the first industrial biorefinery that will transform microalgae into premium, highnutritional-value ingredients for food and cosmetic applications, is a strategic priority. One of our main objectives is to reduce the risks associated with investments that have significant socioeconomic impact. SCALE is the first flagship biorefinery of its kind, developing a whole new value chain dedicated to aquatic resources. It will help reduce the EU’s heavy reliance on imported natural ingredients while acting as a carbon sink. Last but not least, we’re pleased to see an SME taking the lead on this highly qualified project team!” Philippe Mengal, Executive Director of Bio-based Industries Joint Undertaking
SCALE IS SUPPORTED BY A HIGH-PROFILE CONSORTIUM
Microphyt has coordinated a consortium of 11 key partners along the entire value chain.
Each partner is an industry expert and plays a complementary role in the program:- Technology and Energy Solution Providers (Evolys, SUNTI),
- End-users in the Nutrition and Cosmetics Markets (Paul Bocuse Institute, Plameca, Lallemand, Chanel Parfums Beauté)
- Regulatory (Nutrasteward) & Sustainable Development (TECNALIA) Consulting Firm,
- Consulting Firm (PNO) and the Bioeconomy Cluster (IAR).
The whole consortium met on June 30th, 2021 for the SCALE kick-off meeting in the presence of representatives of the European Commission.
“We are really proud to coordinate the SCALE program which foster the transition towards sustainably produced microalgae-based ingredients for nutrition and wellness. Our partners are strongly committed and we’ve received great support from both the European Commission and the BBI JU. SCALE is a key step on Microphyt’s journey as it unlocks the full potential microalgae and its amazing biodiversity.” Vincent Usache, Microphyt CEO
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ABOUT MICROPHYT
Microphyt is a leading company in the production and marketing of microalgae-based natural active ingredients.
With more than 10 years of expertise in the field, Microphyt leverages microalgae’s previously untapped diversity to provide unique solutions for Nutrition and Wellness. Microphyt’s technologies, developed in-house and
patented, enable the controlled production of a wide variety of microalgae sustainably on an industrial scale.
Recent highlights:- A financing round of €28.5 million in June 2019
- The commercial launch in the US of the first nutritional ingredient BrainPhyt, for the prevention of agerelated cognitive decline in 2020
- 4 new and unique natural ingredients in development (2022-2023)
- A sustainable production facility that has quadrupled in output (2020-2021)
- The doubling of our workforce and assembly of a world-class international Supervisory Board (2020)
- Repeated selection by the French government as one of the 123 start-ups that will benefit from the French Tech 120 Program (2020-2021)
For more information visit https://www.microphyt.eu
Follow us on Twitter: @Microphyt and LinkedIn: https://www.linkedin.com/company/2323904/ABOUT BIO-BASED INDUSTRIES JOINT UNDERTAKING
Within the framework of Horizon 2020, Bio-Based Industries Joint Undertaking (aka BBI JU) is a €3.7bn publicprivate partnership between the EU and the Bio-Based Industries Consortium.
Its mission is to boost investments for the development of a sustainable industrial sector driven by bio-industries in Europe. The EU body aims to deliver environmental and socioeconomic benefits for European citizens, shaping and upgrading Europe’s competitiveness and wishes to become a key player in the research, demonstration and deployment of state-of-the-art biofuel products.
BBI JU will also play a key role in building a European bioeconomy.ABOUT HORIZON 2020
Horizon 2020 is the EU’s biggest funding program for Research & Innovation. It focuses on three main priorities: scientific excellence, industrial leadership and societal challenges.
The program came into force on January 1st 2014, merging for the first time in a single program, European Research & Innovation Programs, and providing support for projects throughout the innovation chain.Information and press contacts for stakeholders and investors are available at www.microphyt.eu and :
- Plameca – Spain – www.plameca.com
- Paul Bocuse Institute – France – www.institutpaulbocuse.com
- Lallemand – France – www.lallemand.com
- Chanel Parfums Beauté – France – www.chanel.com
- Fundacion tecnalia research & innovation – Spain – www.tecnalia.com
- Evolys – Norway – www.evolys.no
- Sunti – France – www.sunti.fr
- NutraSteward Limited – UK – www.nutrasteward.com
- PNO Consultants – France – www.pnoconsultants.com
- IAR – The French Bioeconomy Cluster – France – www.iar-pole.com
Download the SCALE Project Press Release
This project has received funding from the Bio Based Industries Joint Undertaking (JU) under grant agreement No 101023593. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and the Bio Based Industries Consortium.
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Astaxanthin: focus on one of the most potent natural antioxidants
Astaxanthin is one of the most sought-after antioxidant supplements these days. This super ingredient occurs naturally in certain algae and once extracted, it has a major impact on the human body. In fact, it’s been linked to a myriad of health benefits.
Let’s take a deep dive into the wonders of the scientific world…
Staying healthy has everything to do with balance. Including the balance between free radicals and antioxidants circulating throughout our bodies. However, this balance may be altered by environmental factors like pollution, stress, alcohol or poor lifestyle habits.
So, what are the consequences for us?
Immediate response: our bodies go into oxidative stress. Oxidative stress occurs when there is an excess of free radicals in the body’s cells. It may become detrimental to the body as it may damage cells, proteins, and DNA, all of which may contribute to premature and accelerated aging. The immune system is then weakened, paving way for the onset of many chronic diseases.
Luckily for us, nature works wonders. Haematococcus pluvialis is a microalgae that produces lots of astaxanthin….which happens to be one of the most potent natural antioxidants known to man.
AN ANTIOXIDANT POWERHOUSE THAT WINS THE DAY
20 years, 100 clinical studies and 500 pre-clinical studies later, scientific results are in and they’re clear-cut [1] : astaxanthin has an outstanding capacity to trap singlet oxygen (aka a molecule that oxidizes various important biological molecules in our body).
So, just how powerful is it?
- Astaxanthin is 6,000 times stronger than vitamin C;
- Astaxanthin is 800 times stronger than coenzyme Q10;
- Astaxanthin is 550 times more effective than vitamin E;
These staggering numbers made it one of the most effective natural antioxidants for mankind, a trump card for a range of health applications.
3 LEADINGS APPLICATION FIELDS
In nutraceuticals, astaxanthin has many proven health benefits, especially on [2]:
- vision and eye health;
- cognitive function and brain health,
- the immune system;
- the cardiovascular system;
In sports nutrition, astaxanthin has an array of powerful anti-inflammatory benefits for individuals suffering from chronic diseases, but also for young, healthy, gym rats. It reduces joint, tendon and muscle pain. [3]
In nutricosmetic, the benefits of astaxanthin have been demonstrated on the skin (appearance, overall health) as it protects against UV rays. [4]
And the list goes on…
AN INCREDIBLE MOLECULAR STRUCTURE
Astaxanthin is a carotenoid that belongs to the xanthophyll family. Its molecular structure keeps free radicals in check with very unique features:
- The lipophilic polyene chain makes it oil-soluble and fat-soluble
- It acts upon cell membranes through its hydrophilic ends
The outcomes? Astaxanthin captures free radicals inside and outside the lipid bilayer of the human body membranes.
How? By penetrating and passing right through them. Astaxanthin acts as a “wall pass” that crosses the blood-brain and blood-retina barriers to release its power.
ORIGINALLY, A MICROALGAE SHOWING HIGH LEVELS OF STRESS
None of this would have been possible without Haematococcus pluvialis, a green, eukaryotic, unicellular microalgae that occurs naturally in the fresh waters of temperate regions, on every continent. It produces astaxanthin when found in stressful environments, such as those induced by a lack of nutrients or an excess of temperature or light.
Disrupted, its cell goes through adaptive biochemical and morphological changes: it then accumulates carotenoids to ensure its survival. The Haematococcus pluvialis microalgae grows and produces astaxanthin which will then change its color, from green to dark red.That’s when this extraordinary antioxidant unleashes its super powers and protect the microalgae’s DNA from UV rays and its cells from various oxidative stresses.
In addition, it serves as an internal nutrient reserve readily available when growing conditions resume. Quite magical!
ASTAXANTHIN AT THE FOREFRONT OF A BOOMING MARKET
As an expert in bioactive ingredients from microalgae, Microphyt is very familiar with all the benefits of Haematococcus pluvialis. Microphyt extracts the astaxanthin pigment by creating optimal growing conditions for Haematococcus pluvialis through patented, state-of-the-art technologies. Microphyt packed all the powers of this super antioxidant in the AstaPAK range, available in various options (powder, oleoresin, softgels) to meet the consumers ever-growing demand for safe and science-based natural products. To find out more about our products, contact us by clicking here!
[1] Zhang et al., 2016.
[2] Sawaki et al., 2002; Nakamura et al., 2004 ; Saito et al., 2012; Yasunori et al., 2005.
[3] Baralic et al., 2015 ; Spiller et al., 2006 ; Fry, 2001 ; Nir and Spiller, 2002.
[4] Yamashita, 2006 ; Lorenz, 2002 ; Tominaga et al., 2017.
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The exposome, a daily challenge for the skin
What exactly do we mean by “exposome”? This little word refers to a whole host of factors which, whether acting on their own or together, have an impact on our health, and especially on our skin. The adaptive capabilities of some microalgae can serve as a source of inspiration and provide us with solutions to protect ourselves. We take a closer look.
What is the exposome?
The exposome refers to all the exposures, both internal and external, that an individual experiences from birth to death. It is therefore seen as a complement to the genome. The term was first coined by Professor Christopher Wild, Director of the International Agency for Research on Cancer, in 2005.
The exposome includes:
– environmental factors such as pollution and UV radiation;
– biological/hormonal changes such as puberty, pregnancy and menopause;
– lifestyle-related factors such as nutrition, fatigue, stress, smoking, etc.
How is the exposome related to health and skin beauty?
The different types of exposure, often invisible, that we experience have a major impact on our body and especially on our skin, the primary barrier that separates and protects us from the outside world. It is thought that only about 25% of skin aging is determined by our genes. The exposome is responsible for the remaining 75%.[1]
Some of the more harmful factors for the skin include UV radiation, pollution, smoking, diet and stress. They all act on different functions, such as the barrier effect and also pigmentation and structure, with a major impact on health.
If we take each factor individually, the damaging effects on the skin may appear to be relatively small. But synergies can emerge and amplify the impact. This is the case with UV radiation in conjunction with pollution, for example. Recent research has shown that together, they have significant negative consequences for the skin[2] and are responsible for premature skin aging.[3]
How can we limit the synergistic effect of UV radiation and pollution?
Microphyt has designed a cosmetic ingredient that is capable of amplifying and optimizing the skin’s natural defenses, protecting it from the harmful combined effects of UV rays and pollution. It works by harnessing the potential of the microalgae Porphyridium cruentum, which over the past 625 million years has developed the ability to resist and adapt to a variety of extreme environments. The active ingredient, obtained by naturally extracting Porphyridium cruentum, is powerful and rich in phycoerythrin and exopolysaccharides, two synergistic bioactive molecules that are highly effective in tackling external aggressions, in particular by protecting DNA from combined exposure to UV radiation and pollution. To find out more about Renouvellance, a natural marine solution to reduce Urban Photo Stress for a more healthy, radiant complexion, click here.
[1] https://cosmeticobs.com/fr/articles/compte-rendus-congres-48/pensez-exposome-de-ses-effets-sur-la-peau-aux-nouveaux-actifs-pour-les-combattre-4082
[2] https://www.sciencedirect.com/science/article/pii/S2213231719313874
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583881/
Image source: Image by StockSnap from Pixabay
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Porphyridium cruentum: 5 amazing properties of this remarkable microalgae attractive for the cosmetic
We take a closer look at the incredible potential of Porphyridium cruentum, a microalgae rich in bioactive compounds very useful for the skin.
Porphyridium cruentum is a resilient and highly adaptable red microalgae with a wide array of benefits. It contains multiple molecules of interest that can be used to develop ingredients that offer real results for the skin. Already well known by cosmetics experts for its moisturizing and anti-inflammatory powers,1 Porphyridium cruentum has also been proven to have excellent protective and anti-aging properties. With Renouvellance, Microphyt has harnessed the potential of Porphyridium cruentum to boost and protect the skin. Read on to learn more about this microalgae that deserves to be better known.
1. IMPRESSIVE ADAPTIVE CAPABILITIES
Porphyridium cruentum is an ancient microalgae that first appeared more than 625 million years ago and has survived over time by adapting to its environment. This extraordinary microalgae is capable of withstanding extreme environmental conditions such as excessive exposure to sunlight, drastic temperature fluctuations and intense hydric and osmotic stress.
2. ABILITY TO DEFY ENVIRONMENTAL STRESSES
It may be microscopic in size, but this highly adaptable microalgae has developed a formidable system of defense composed of powerful multifunctional molecules that act on every level. Porphyridium cruentum synthesizes compounds capable of providing it with effective protection against environmental stresses, from exopolysaccharides at the cell wall to carotenoids and phycobiliproteins within the cell.2
3. A PROTECTIVE COCOON
Exopolysaccharides are secreted marine polymers composed of xylose, glucose, galactose and glucuronic acid that surround the microalgae with a protective coating. Their main roles are to protect cells from dehydration and maintain cell rigidity so that the microalgae can develop in a wide range of environments including marine, airborne and freshwater habitats. Since exopolysaccharides also serve as chelating agents for heavy metals, they also have anti-pollution properties.
4. A POWERFUL ANTIOXIDANT
Phycobiliproteins are photosynthetic pigments that are responsible for the unique color of Porphyridium cruentum. They capture light energy, which they then transfer to the photosynthetic reaction center. They are powerful antioxidant chromophores. The main biliproteins found in Porphyridium cruentum microalgae are allophycocyanin (5%), R-phycocyanin (11%), B-phycoerythrin (42%) and B-phycoerythrin (42%).3
5. GENERATES FATTY ACIDS, CAROTENOIDS, MINERALS AND VITAMINS
Porphyridium cruentum also contains lipids, especially polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and arachidonic, palmitic and linoleic acid. It is also known to synthesize carotenoids including zeaxanthin, and contains various essential microelements such as calcium, potassium, sodium, magnesium, tocopherol (vitamin E) and vitamin K2.
A REMARKABLE MICROALGAE
Porphyridium cruentum belongs to the family Porphyridiaceae and the division Rhodophyta. It is a single-cell microalgae in the form of tiny red/pink pearls which are invisible to the naked eye. It grows naturally in various locations, for example in the seawater around the Brittany coastline in France or in the Coral Sea off Australia. More surprisingly, it has also been identified in extreme terrestrial environments such as the Negev Desert in Israel.
RENOUVELLANCE – CONCENTRATING THE POTENTIAL OF PORPHYRIDIUM CRUENTUM
Microphyt grows this microalgae on a large scale using its exclusive patented hydro-biomimetic technology. CAMARGUE photobioreactors reproduce the natural conditions for the development and growth of Porphyridium cruentum in a closed environment in which each parameter – temperature, light, movement, etc. – is carefully monitored, enabling the controlled, standardized production of molecules of interest. Microphyt also extracts this concentration of bioactive molecules at its production platform using green solvents. Renouvellance is rich in phycoerythrin and exopolysaccharides. It enhances and optimizes the skin’s natural defenses, protecting it from the harmful combined effects of UV rays and pollution.
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Nutrition and health: Fucoxanthin, the brain’s natural ally
Fucoxanthin is a powerful, scientifically recognized antioxidant derived from microalgae that maintains and boosts cognitive function. Microphyt harnesses the powers of fucoxanthin in its product BrainPhytTM.
Maintaining the brain’s ability to think and interact is a challenge at every stage of life. Fucoxanthin is a scientifically proven natural molecule with specific properties that reduces oxidative stress on the brain and helps preserve cognitive function. Microphyt has leveraged its potential in its compound BrainPhytTM for nutrition and health.
PRESERVING AND BOOSTING THE BRAIN’S ABILITY: THE CHALLENGE OF OUR CENTURY
Our cognitive functions, in other words the brain’s ability to think and interact, evolve throughout our lifetime. The challenge facing us all is to maintain a high level of mental activity and to age well, regardless of what stage of life we are in.
During periods of learning, and especially in higher education, stress can make it difficult to cope and cause memory lapses. By boosting our cognitive performance, we can absorb information more effectively, improve memorization and concentration, and be better prepared to deal with situations of tension.
Once we reach adulthood, in professional and/or family environments, maintaining a good level of cognitive function is vital to ensure that we are mentally at our best every day and to help us manage our daily routine calmly and with confidence.
For those in the latter years of life, age-related cognitive decline can be a constant battle, with symptoms ranging from a reduced concentration span to memory loss and difficulties communicating. By maintaining the brain’s capabilities, elderly people can become more independent and sustain their social connections for longer.
At all ages, decline in cognitive function is exacerbated by multiple external factors such as poor diet, stress, pollution, tobacco and alcohol, which generate oxidative stress.
Over the past few years, scientific research on microalgae has revealed natural molecules that offer an effective solution to live better for longer.
FUCOXANTHIN: A REMARKABLE PROTECTOR FOR THE BRAIN
Fucoxanthin is a molecule found naturally in some algae and microalgae, such as Phaeodactylum tricornutum. This pigment from the carotenoid family is a powerful antioxidant which protects the body’s cells from free radicals and therefore also from the effects of aging.
What is remarkable about fucoxanthin is its ability to cross the blood-brain barrier (the physiological barrier between the blood and the central nervous system). Extensive preliminary research suggests that this capability, unique in molecules of this type, helps reduce certain biomarkers such as IL-6 and LPM in brain cells. How does it work? Fucoxanthin acts directly on microglial cells, the main form of immune defense in the central nervous system. Fucoxanthin is also effective in activating the mechanism that eliminates intracellular waste in brain cells caused by oxidative stress. If this waste is not eliminated, oxidative stress and the damage it causes are further exacerbated.
So by reducing IL-6, LPM, oxidative stress and their consequences on the brain, fucoxanthin helps prevent cognitive decline, enabling us to maintain our mental capabilities and to age more healthily.
THE POWER OF FUCOXANTHIN CONCENTRATED IN BRAINPHYTTM
Microphyt, a pioneer in microalgae-based natural solutions for nutrition and well-being, has designed and developed a patented state-of-the-art technology: CAMARGUE photobioreactors. Using this innovative technique, Microphyt can grow Phaeodactylum tricornutum microalgae in a closed environment, in a controlled, sustainable and environmentally-friendly way. The subsequent extraction process isolates the useful molecules (both individual molecules and molecules acting in synergy) for their health benefits. This was the process used by Microphyt to develop BrainPhytTM, a compound derived from Phaeodactylum tricornutum and composed of several bioactive molecules – including fucoxanthin for its antioxidant properties that help maintain cognitive function. BrainPhytTM has proven to be effective in seven preclinical studies and is currently the focus of a human clinical trial, the results of which will be available in 2022.
To know more about this ingredient, click here.
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Microphyt strengthens its development in the US
- Microphyt Inc. is the new subsidiary of Microphyt France based in the USA with sales offices in PA and MA.
- Mr. Ilya Zhivkovich, Chief Business Officer of Microphyt based in the USA, assumes responsibilities of managing Microphyt Inc. and also global marketing and sales activities of innovative bio-actives ingredients for nutrition and personal care industries.
- Microphyt Inc. announces its first partnership with Premier Specialties, for promotion and distribution of Microphyt’s cosmetic ingredients in the USA.
Baillargues, France (February 12th 2021) – Microphyt France, a leading company in microalgae-based natural bio-actives for nutrition and personal care industries, announces its newly created US subsidiary, Microphyt Inc. with sales and marketing offices located in Massachusetts and in Pennsylvania, Microphyt Inc. will focus on growing company’s customers base in NA. Mr. Ilya Zhivkovich, Chief Business Officer of Microphyt will assume responsibilities for managing Microphyt Inc. Mr. Ilya Zhivkovich has more than 25 years’ experience in global sales, marketing and general management positions across food and nutrition. He has an extensive track record of developing and executing Go-To-Market strategies for innovative high value, scientifically backed products.
Microphyt’s new subsidiary announces its first partnership, Premier Specialties:
To accelerate the launch of its cosmetic ingredients portfolio in the US Microphyt Inc. has reached an agreement with Premier Specialties for promotion and distribution.
“Microphyt is excited to partner with Premier Specialties. We are confident that Premier’s vast and long-standing relationships within the personal care industry combined with Microphyt’s robust innovation pipeline will yield new solutions for brands and consumers passionate about science-based, natural, sustainably-produced bio-actives from micro-algae.” said Mr. Ilya Zhivkovich, CBO.
“Partnering with Microphyt expands Premier’s natural cosmetic offer to include unique microalgae bioactives; creating advances in skincare science using green technology”, said Ms. Francesca Muia, VP Natural Cosmetics Division, Premier Specialties.
About Microphyt
Microphyt is a real French innovative and a leading company in the production and marketing of microalgae-based natural active ingredients. With more than 10 years of expertise in this field, Microphyt draws from the untapped microalgae diversity to provide unique solutions for Nutrition and Wellness. Microphyt’s technologies, developed in-house and patented, allow the controlled production of a wide variety of microalgae on an industrial scale and in a sustainable way. The company has 30 employees and has filed 5 patent families.
More information: www.microphyt.eu – Follow Microphyt on LinkedIn and Twitter: @Microphyt
About Premier Specialties
Premier Specialties, Inc. is a global creator of Fragrances for the Personal Care, Beauty, Home, Fabric and Air Care markets. The diverse Premier portfolio also includes Flavor Compounds (Halal and Kosher) and world class Natural, Organic and Sustainable materials for the Cosmetic and Personal Care Industries. Premier Specialties has achieved a Silver Ecovadis rating.
More information: www.premierfragrances.com – Follow Premier Specialties on LinkedIn and Twitter: @premspec_
Microphyt’s Contacts
Ilya ZHIVKOVICH – Chief Business Officer – ilya.zhivkovich@microphyt.eu
Julie PERSON – Corporate Communication Manager – julie.person@microphyt.eu
Premier Specialties’ Contact
Francesca MUIA – VP Natural Cosmetics Division – francesca.muia@premierfragrances.com
Image source: Image by Felix Dilly from Pixabay
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Microphyt sponsors the SFC E-Symposium on the theme Skin and Emotions
The first international SFC (French Society of Cosmetology) e-symposium will be on online from December 3rd to the 18th. It will be the opportunity to discover the latest advances and innovations on Skin & Emotions.
Register to the event and discover a short video by Cyrielle Houdin, Microphyt Cosmetic Marketing Manager on our main lines of research as well as our most recent work on neuronal skin and the effects our innovated bio-actives based on microalgae.
And if you want to know more:
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Environment: microalgae to the planet’s rescue
In the living world, it is sometimes the smallest organisms that play the biggest role in maintaining the balance our planet needs. Microalgae, microscopic marine plants, were among the first living organisms that fostered life on earth. Today, they are vital in reducing the effects of pollution and responding to the climate challenge.
The first link in the aquatic food chain, microalgae have been living in our seas, lakes and streams for billions of years. We estimate that there are between 200,000 and several million species in the wild. Without them, life as we know it would not be possible.
Why are they so important? Their physiological functioning and photosynthesis mean that:
- They are powerful carbon sinks that trap CO2 from the atmosphere
- They release 2/3 of the oxygen they breathe, representing half the oxygen in the atmosphere
- In our seas and oceans, they help absorb 90% of additional heat generated by greenhouse gases
- They synthesize organic molecules vital for life from light and minerals, offering us impressive concentrations of active compounds: protein (up to 75% of their dry weight, twice as much as soya beans), amino acids (5-20 %), carbohydrates (up to 20 %), lipids, Omega-3, vitamins, trace elements (cooper, iron and zinc) and mineral salts.
Developed during the 20th century, microalgae cultivation techniques have been perfected. Today, microalgae are generating interest across many sectors from food to well-being, pharmaceuticals, cosmetics and aquaculture. Following the 1979 petrol crisis, we also began exploring ways to combine them with biofuels as an energy source.
Reducing pollution
The way their metabolism works has many advantages for the environment, and in particular, fighting pollution. Building on tried-and-test methods, a multitude of experiments are widening their scope within our ecosystem:
- Treating used water (lagooning): microalgae feed on nitrates, nitrogen and other oxides to purify water
- Recycling industrial fumes: carbon dioxide (CO2) and nitrogen oxides (Nox) are captured by microalgae, limiting greenhouse gas emissions
- Bio-filters in urban areas: capable of absorbing up to 99% of fine particles and up to 97% of nitrogen oxides, microalgae are increasingly being integrated into urban landscapes, for example, in bio-facades, bio-columns or asphalt
Carbon sinks to save the oceans
Microalgae are one of proposed solutions for reaching the Paris Agreement target of keeping global temperature rise this century below 2°C. But global warming is also having an impact the temperature of seas and oceans, disrupting marine biodiversity and their capacity to absorb CO2. Protecting marine ecosystems, while also encouraging innovation in controlled microalgal cultivation is therefore more important than ever. Microalgae enabled humans to live on earth. The time has come to ensure that they too can live and grow in the right conditions.
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Everything you need to know about cultivating microalgae
With no competition for land, faster reproduction cycles than most plants, numerous co-product possibilities and a positive environmental impact, microalgae cultivation is generating interest across a multitude of markets. But for each application, it is important to choose the right technique and technology.
Let’s take a look at the different microalgae culturing methods.
Microalgae were one of the first living organisms on earth. Although some – like Spirulina and Nostoc – have been harvested for many centuries, cultivation and extraction techniques were only developed from the middle of the 20th century. Since, then, the range of applications continues to grow:
- Nutrition and phytopharmacy
- Cosmetics
- Agriculture
- Energy
- Depollution
To culture microalgae and extract their active ingredients at an industrial scale, today there are three types of technology developed progressively over the last 50 years: open systems (Open ponds/Raceway), fermentors and photobioreactors.
Pioneering microalgae cultivation: open systems
In France, microalgae cultivation began in the late 1970s with open-air systems using discontinuous basins and semi-controlled conditions. Over the years, these culturing systems have been perfected. Among the most widely used are raceway flow-through systems with their distinctive racing-track format. Easy to manage with limited investment costs, these open systems can be used to cultivate only the most robust (even extremophile) microalgae like Spirulina. The microalgae are exposed to climatic variation and the risk of contamination e.g. predators, bacteria and other microalgae. These constraints make open systems the least productive method in terms of microalgal diversity – see table.
Fermenters for specific products
Microalgae can also be cultured in a completely closed fermenter system. With no light source, the microalgae stop photosynthesizing but still breathe using sugar as a source of energy. This technique requires strict sterile conditions. As this technique deprives microalgae of light, it can only be used for certain varieties and therefore for a limited range of products. The advantages? High volume-based productivity and low production costs. In recent years, mixed processes have been developed in an attempt to combine the advantages of autotrophic and heterotrophic systems.
Photobioreactors, inspired by nature
In 1957, at MIT (Massachusetts Institute of Technology, USA), the first photobioreactor (PBR) was developed. As a closed system, the photobioreactor recreates an optimal biotope for microalgae, which are stimulated using a natural or artificial light source. The vertical or horizontal tubes are transparent meaning that photosynthesis can usually occur (autotrophic system). The growing conditions are controlled – nutrients are added, and the temperature, pH and dissolved oxygen monitored. The microalgae therefore grow in an environment very similar to their natural habitat.
Camargue: innovative photobioreactors
In 2009, Microphyt developed and patented a unique, biomimetic process baptized Camargue, which tackles the main challenges of cultivating fragile microalgae at an industrial scale using photosynthesis. Currently, the 20 tubular 5000-liter photobioreactors covering 55 m and standing at 3.8m offer:
- A wider field for microalgal investigation than other industry players
- Quality and traceability with a closed environment controlled at every step
- High, multi-product production capacity
- A process that respects the environment
Beyond technical, performance and financial considerations, the choice of microalgae cultivation method also depends on the characteristics of the different microalgae varieties and their valorization. Not to mention the environmental impact.
For more information on Camargue photobioreactor technology, click here.
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Asterionella formosa: a delicate microalga perfect for cosmetics
Let’s delve deeper into Asterionella formosa, a microalga that stands out from the crowd with exceptional advantages for cosmetic products.
Asterionella formosa, a diatom (brown) microalga, has a lot to offer us and our wellbeing. Unlike other Asterionella, A. formosa evolves in temperate climates, preferably in fresh water at 10-15°. But it is very good at adapting – one of its main advantages. Measuring no more than 60 micrometers (0.06 mm), this “colonial” microalga can reproduce in much lower temperatures, as well as in environments where nutrients are scarce.
Another big advantage? Asterionella formosa is a biomarker that identifies negative human impacts on the environment like the eutrophication of lakes (Asterionella proliferates) and their acidification (Asterionella populations decrease). It is therefore invaluable for Paleoecology and Paleolimnology[1] experts looking to reconstruct the sedimentary past of inland waters.
The microalga with multiple benefits for cosmetics
Cosmetics industry professionals are keeping a close eye on this microalga. The external structure is rich in biogenic silica, a trace element essential for protecting and reinforcing the skin, hair and nails. It also produces:
- Fucoxanthine, a molecule with antioxidant, anti-inflammatory and fat-burning properties
- Long-chain polyunsaturated omega 3 fatty acids essential to human health
- A, B and C asterionelines with anti-inflammatory properties
- Phycosterols (β-sitosterol) that act as anti-inflammatory, antioxidant, cholesterol-regulating agents
Fragile yet strong
It is no coincidence that Micophyt chose the microalga’s star-shaped structure for its logo. This reference alludes to the top-ranking French startup’s technological capacity to develop even the most delicate microalgae on a large scale. As is the case for Asterionella formosa. “Very few are able to cultivate it in an artificial environment that enables mass production. Its fragility and nutritional needs require adapted technology,” explains Rémi Pradelles, Microphyt’s Research & Development Director. In 2015, the company included Asterionella formosa as one of the 40 most promising microalgae in the SMILE[2] project, launched in collaboration with CEA. The aim? Observe how these microalgae grow in a closed environment.
Innovative technology to get the best from microalgae
In Microphyt’s laboratory, Asterionella formosa has unveiled many of its secrets, in particular its metabolic growth levers. The next step? Producing it in a controlled, standardized environment in industrial conditions. And, this is where Camargue® technology – a unique production process designed and patented by Microphyt – comes in. The 5000-liter tubular photo-bioreactors recreate smooth wave patterns while also preserving the cellular integrity of fragile microalgae including Asterionella formosa. This is excellent news for anyone looking to co-develop differentiating cosmetic products based on a microalga that actively promotes wellbeing.
Microphyt Camargue Photo-bioreactors [1] Paleolimnology refers to studying the history of inland waters (including lakes, steams and wetlands) by analyzing sedimentary deposits.
[2] The SMILE (Slimming and Memory booster mIcroaLgae Extract) program aims to develop, produce and commercialize active natural ingredients extracted from specific microalgae that contribute to weight loss and maintaining cognitive functions. This program is supported by the European Union.
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Coronavirus : our production site and labs continue to operate
Dear custumers, partners and suppliers,
The President of the Republic announced strong measures to prevent the spread of the Coronavirus. It is in this unprecedented context in France, that we wanted to inform you that Microphyt maintains its activity until now.
All hygiene and safety measures have been taken to preserve the health of our teams and to guarantee you :
the administrative and commercial follow-up of your orders, thanks to teleworking measures.
the production of our products, in order to honour your orders and ensure supplies as far as possible.Should one of the links in the chain be impacted, we will keep you informed of any changes and solutions implemented.
On behalf of the entire team, we thank you for your trust and loyalty.
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French Tech 120 : Microphyt among the most promising start-ups.
Microphyt, a specialist in the production of natural ingredients made from microalgae, is one of the 123 promising start-ups selected to join the French Tech 120 programme. This will provide an amazing springboard for the domestic and international development of its microalgae-based natural solutions for nutrition, well-being and cosmetic
On January 20th 2020, the French Government announced the list of the 123 start-ups selected to receive support as part of French Tech 120, an exceptional programme that focuses on companies in a phase of hyper-growth with the potential to become future world leaders. This recognition rewards Microphyt’s strategy of innovation and differentiation.
With the help of this acceleration programme, Microphyt intends to strengthen its industrial development, recruit to increase organic growth and facilitate the regulatory approval of its products worldwide..
“Being part of the French Tech ecosystem is recognition for our teams and our investors who believed in the strong potential of Microphyt from the start. The flexibility and performance of our processes allow us to innovate faster than others and to propose original natural solutions. Becoming a part of the French Tech programme is an opportunity for Microphyt to gain visibility and consolidate its progress”, says Microphyt’s CEO, Vincent Usache.
A tribute to Microphyt’s technology and expertise
Microphyt has patented an environmentally friendly, entirely in-house production process that is one of a kind. Thanks to this process, it can study a wide variety of microalgae and identify their best active ingredients, before growing them on a very large scale in a controlled environment.
Microphyt develops natural microalgae-based solutions in the fields of nutrition and wellness that aim to prevent age-related cognitive decline, joint pain and certain metabolic disorders such as prediabetes and excess weight. Microphyt also produces a range of natural anti-aging, moisturizing and photoprotective ingredients for the cosmetic industry.
At the end of 2019, the American Food and Drug Administration (FDA) granted New Dietary Ingredient (NDI) status to PhaeoSOL, one of the ingredients developed as part of the SMILE programme. NDI status will allow Microphyt to market PhaeoSOL as an ingredient for dietary supplements. Several (preclinical) studies have demonstrated the benefits of PhaeoSOL in the prevention of age-related cognitive decline.
A promising market and the confidence of investors
Microphyt sells specialised, microalgae-based natural ingredients for niche markets with high added value in the nutrition (dietary supplements), wellness and cosmetics sectors.
These fast growing markets represent a value of 50-70 billion dollars worldwide, with an annual growth rate of 2-4 %.
To meet demand and accelerate the development of its product portfolio, Microphyt raised € 28.5 million in 2019, one of the highest amounts worldwide in its sector.
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Microphyt’s PhaeoSOL receives New Dietary Ingredient (NDI) Status from the FDA.
- PhaeoSOL is a natural microalgae-based bioactive aiming at improving the well-being of the elderly by supporting the maintainance of cognitive function.
- Backed by proprietary efficacy data, PhaeoSOL key benefits will be presented at the 2019 Supply Side West show in Las Vegas (USA)
- Microphyt is the first European microalgae company which has received NDI Status from the FDA
Baillargues (France), October 15th, 2019 – Microphyt, a leading company in microalgae-based natural solutions for nutrition and well-being, announced that it has received New Dietary Ingredient (NDI) status from the Food and Drug Administration (FDA) for its patented PhaeoSOL dietary ingredient. This decision allows Microphyt to accelerate the commercialization program of its lead product in the United States, the world’s largest market for nutrition and well-being natural ingredients.
Microphyt received the FDA’s Acknowledgement Without Objection letter within its 75-day evaluation period to respond. The recommended conditions of use allow a safe and high-dose of this ingredient in the dietary supplements. Proprietary preclinical data on PhaeoSOL have demonstrated significant nutritional benefits in the prevention of age-related cognitive decline. Compared to standard natural ingredients, the superior efficacy of PhaeoSOL was demonstrated and was associated with the synergy of unique bioactive compounds.
PhaeoSOL will first be presented at the SupplySide West show in Las Vegas, the largest gathering of health & nutrition professionals that takes place October 15-19, 2019. The world market for ingredients for these markets, represents more than US$ 70 billion with a share of natural ingredients (US$ 5 billion) that shows the strongest growth (8% per year). Among the natural ingredients, microalgae best meet consumer expectations thanks to their natural diversity, offering richness of molecules that can be produced in a close-controlled and sustainable way.
PhaeoSOL is produced in Microphyt’s proprietary production technology. This patented process, developed in-house, solves the usual drawbacks of microalgae production. It is based on 5,000-litre tubular photobioreactors, which offer both high differentiation potential (access to a new diversity of species) and the ability to supply natural active ingredients in an industrial and standardized way. This technology, operated within an industrial production platform, has already made it possible to establish several commercial partnerships with key players in the sector.
Virginie Wasiolek, Regulatory Affairs Manager at Microphyt indicated « Thanks to the dedication of the whole Microphyt team, we have been able to place on the market our first flagship ingredient PhaeoSOL which is backed by a strong body of science and intellectual property. The FDA’s decision confirms PhaeoSOL’s safety”.
Vincent Usache, Microphyt’s CEO, said “This NDI notification is a significant milestone in our development and opens the door to the commercialization of PhaeoSOL in the US, which is the world-leading market for dietary supplements”.
In addition of PhaeoSOL, and following its latest funding of €28.5 million, Microphyt is pursuing the development of its portfolio of microalgae-based natural solutions for nutrition and well-being with 10 nutritional active ingredients and 20 cosmetic active and functional ingredients being developed.
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Microphyt raises €28.5 million to develop its portfolio of microalgae-based natural solutions for nutrition and well-being
Microphyt Camargue Photobioreactors - Microphyt secures one of the largest fundraising in the microalgae sector
- The round was co-led by Sofinnova Partners and Bpifrance, through its SPI Fund
- The funds will allow Microphyt to bring to market its range of natural products for nutrition and well-being and to develop its production capacity and its proprietary microalgae culture technology
Baillargues (France), July 11th, 2019 – Microphyt, a leading company in microalgae-based natural solutions for nutrition and well-being, announced a fundraising of €28.5 million (US$32 million). This investment was co-led by Sofinnova Partners and Bpifrance, through the “Sociétés de Projets Industriels” fund (“SPI fund”), together with IXO-Private Equity and Sofilaro. The existing investors, Supernova Invest, Demeter Partners and Irdi Soridec, renew their confidence in the company by participating in this new round. The funds will be used to accelerate the development of the product portfolio, to expand sales network globally, as well as to increase production capacity of Microphyt’s industrial platform.
In nutrition and wellbeing, consumer demand for natural, effective, safe and sustainably produced solutions is booming. The world market for ingredients for these markets, represents more than US$ 70 billion with a share of natural ingredients (US$ 5 billion) that shows the strongest growth (8% per year). Among the natural ingredients, microalgae best meet consumer expectations thanks to their natural diversity, offering richness of molecules that can be produced in a close-controlled and sustainable way.
Since 2009, Microphyt has developed a proprietary production technology that makes it possible to access this diversity while guaranteeing a high level of control and standardization. This patented process, developed in-house, solves the usual drawbacks of microalgae production. It is based on 5,000-litre tubular photobioreactors, which offer both high differentiation potential (access to a new diversity of species) and the ability to supply natural active ingredients in an industrial and standardized way. This technology, operated within an industrial production platform, has already made it possible to establish several commercial partnerships with key players in the sector.
Microphyt has also launched the development of new products that contribute to improving the wellbeing of the elderly, facilitating an active lifestyle and protecting the skin from various stresses. A portfolio of 10 nutritional active ingredients and 20 cosmetic active and functional ingredients is being developed. To achieve this, Microphyt will strengthen its team and will significantly increase its ingredient production capacity over the next 18 months.
“This new round is a major milestone in our development and we are pleased that recognized investors in the sector such as Sofinnova Partners and Bpifrance are joining us alongside our existing investors to accelerate our development and internationalization,” said Vincent Usache, CEO of Microphyt. “For several years now, Microphyt was actively committed to unlocking the full potential of microalgae amazing diversity through our unique technology platform. With this funding, we will speed up the development and supply of novel natural products that solve the key challenges of Nutrition & Wellbeing”.
“Microphyt is exactly the type of company that Sofinnova Partners is looking for as a pioneering investor in industrial biotechnology: thanks to its proprietary technology platform and unique production capacity that allows access to the exceptional biodiversity of microalgae, the company is in an ideal position to become one of the world leaders in natural ingredients dedicated to nutrition and well-being,” says Denis Lucquin, Managing Partner of Sofinnova Partners.
“Microphyt’s innovations are also based on an innovative industrial project,” explains Jean Philippe Richard, Investment Director of Bpifrance SPI Fund. “We share this ambition to develop a leading industrial production site in France and to create a European leader with a global vocation. The site will offer multi-product production with high added value while implementing environmentally friendly processes.